伊尹汤液之谜——中药复方非典型药理效应规律发现与评价策略  

Mystery of Yiyin decoction theory:rule discovery and evaluation strategy of atypical pharmacological effects of Chinese medicinal prescription

作　　者：戴瑛[1] 张翼冠[1] 曾瑾[1] 华桦[1] 赵军宁[1] 李莉[1] 鄢良春[1] 尹竹君 王剑波 谭鹏 谭蕊蓉 曾安琪 全云云 魏平 DAI Ying;ZHANG Yi-guan;ZENG Jin;HUA Hua;ZHAO Jun-ning;LI Li;YAN Liang-chun;YIN Zhu-jun;WANG Jian-bo;TAN Peng;TAN Rui-rong;ZENG An-qi;QUAN Yun-yun;WEI Ping(Sichuan Institute for Translational Chinese Medicine,Sichuan Academy of Chinese Medical Sciences,Key Laboratory of Biological Evaluation of Traditional Chinese Medicine Quality of National Administration of Traditional Chinese Medicine,Translational Chinese Medicine Key Laboratory of Sichuan Province,Sichuan Engineering Research Center for Authentic Medicine Formation Principle and Quality Evaluation,Sichuan Engineering Research Center for Authentic Medicine System Development,Chengdu 610041,China)

机构地区：[1]四川省中医药科学院四川省中医药转化医学中心国家中医药管理局中药质量生物评价重点研究室中医药转化医学四川省重点实验室四川省道地药材形成原理与品质评价工程研究中心四川省道地药材系统开发工程技术研究中心,四川成都610041

出　　处：《中国中药杂志》2022年第16期4261-4268,共8页China Journal of Chinese Materia Medica

基　　金：国家重点基础研究发展计划(973计划)项目(2009CB522801);国家重大新药创制专项(2015ZX09501004-001-005,2011ZX09401-304);国家支撑计划项目(2012BAI29B10);国家自然科学基金面上项目(81073047,81470180);四川省杰出青年基金团队项目(2017TD0003);四川省杰出青年科技人才项目(2020JDJQ0063);四川省科技计划重点研发项目(2020YFS0566)。

摘　　要：伊尹制汤液而始有方剂,由此发展出的现代中药复方及其制剂以其在慢性多因素性疾病的良好治疗效果而备受关注,代表了未来新药发现的一个重要方向。中药复方具有特殊的或者被忽视的独特作用原理,这与单一成分作用的“神弹理论”有较大差别,也与现代多靶点药物的内涵不尽相同。“伊尹汤液理论(Yiyin decoction theory)”是基于现代科学技术方法描述和阐释这种具有超前意识的个性化组合用药的特殊药理效应机制,既考虑到疾病/证候的非稳定性,也注意到疾病在受到药理干扰时表现出来的顽固性和自适应性,以及疾病的多因素病因之间相互关联性,作者把其科学内涵概括为“复方配伍,多重效应,适度调治”。复方配伍涉及组成药物君臣佐使药之间复杂性相互作用。多重效应涉及多种常规的以及非常规的作用机制、非线性反馈相互作用的综合药理效应。适度调治则反映其最终可从整体上精准地实现对疾病生物网络的多点嵌套调控。要破解“伊尹汤液”之谜,并非仅仅简单研究已知活性物质(成分)及其在混合物中独立的靶点作用,更需要重新发现和认识中药复方的“暗物质”“暗效应”,即常规药理效应规律之外的、被忽视的非典型药理效应规律以及在生物体内发挥精准调控功能的多点嵌合机制。伊尹汤液理论聚焦中药复方的整体药理效应规律以体现其综合的临床价值,对于发展符合中医药理论的中药复方新药评价与转化应用新模式具有重要意义。Yi Yin,a famous medical scientist and culinary master in the late Xia Dynasty and early Shang Dynasty,developed the Chinese medicinal liquids and Chinese medicinal prescriptions emerged after that.Chinese medicinal prescriptions have attracted much attention because of their unique advantages in the treatment of chronic multifactorial diseases,representing an important direction of drug discovery in the future.Yiyin decoction theory is the superior form of personalized combined medication with advanced consciousness.It is different from not only the magic bullet theory of single component action but also the connotation of modern multi-target drugs.The core of Yiyin decoction theory can be summarized as compound compatibility,multiple effects,and moderate regulation.Compound compatibility refers to that the formulation of Chinese medicinal prescriptions involves the complex synergy and interactions between sovereign,minister,assistant,and guide medicinal materials.Multiple effects mean that the prescriptions employ a variety of mechanisms to exert comprehensive pharmacological effects of nonlinear feedback.Moderate regulation reflects that the prescriptions can accurately regulate the multiple points of the disease biological network as a whole.To solve the mystery of Yiyin decoction theory,we should not only simply study the known active substances(components)and their independent target effects in the mixture,but also mine the"dark matter"and"dark effect"of Chinese medicinal prescriptions.That is,we should learn the neglected atypical pharmacological effects of Chinese medicinal prescriptions and the multi-point nesting mechanism that plays a precise regulatory function in the body.Yiyin decoction theory focuses on the overall pharmacological effect to reflect the comprehensive clinical value of Chinese medicinal prescriptions,which is of great significance for the development of a new model for the evaluation and application of new Chinese medicinal prescriptions in line with the theory of traditional Chinese

关 键 词：伊尹汤液 中药复方 神弹理论 多靶点药物 非典型药理效应 适度调节原理 

分 类 号：R285[医药卫生—中药学]