雷公藤属植物中倍半萜吡啶大环内酯类生物碱的波谱学特征  

Spectral characteristics of sesquiterpene pyridine alkaloids from Tripterygium plants

作　　者：闫建功 吴先富[1] 陈明慧 戴忠[1] 王亚丹[1] 马双成[1] YAN Jian-gong;WU Xian-fu;CHEN Ming-hui;DAI Zhong;WANG Ya-dan;MA Shuang-cheng(National Institutes for Food and Drug Control,Bejing 100050,China;Tradional Chinese Medicine Procssing Technology Innovation Center of Hebei Province,Hebei University of Chinese Medicine,Shjiazhuang 050200,China)

机构地区：[1]中国食品药品检定研究院,北京100050 [2]河北中医学院河北省中药炮制技术创新中心,河北石家庄050200

出　　处：《中国中药杂志》2022年第16期4292-4304,共13页China Journal of Chinese Materia Medica

基　　金：中国食品药品检定研究院中药所学科建设项目(1020050090113)。

摘　　要：倍半萜吡啶大环内酯类生物碱(简称大环内酯类生物碱)是雷公藤属植物中的一类重要成分,具有抗炎、免疫抑制、抗肿瘤、抗病毒、杀虫等广泛的药理活性,研究价值较大。其结构是由高度氧化的二氢-β-呋喃倍半萜与吡啶二羧酸通过酯键连接而成,根据吡啶二羧酸片段的结构特点可以将其分为多种结构亚型。目前,已从雷公藤属植物中分离鉴定的大环内酯类生物碱有110余种。该文详细总结了雷公藤属大环内酯类生物碱的结构特征及波谱学规律,包括紫外光谱(UV)、红外光谱(IR)、质谱(MS)和核磁共振波谱(NMR),并归纳出该类成分的结构解析流程,为其深入研究和开发提供参考。Sesquiterpene pyridine alkaloids are important components in Tripterygium plants, possessing a wide range of pharmacological activities, such as anti-inflammation immunosuppression, anti-tumor, anti-virus, and deinsectization, and are of great research value. They are composed of highly oxidized dihydro-β-furansquiterpene and pyridine dicarboxylic acid through ester bonds. According to the structural characteristics of pyridine dicarboxylic acid fragments, they can be divided into various structural subtypes. Up to now, more than 110 sesquiterpene pyridine alkaloids have been isolated and identified from Tripterygium plants. This study reviewed the structural features and spectral(i.e., UV, IR, MS, and NMR) characteristics of sesquiterpene pyridine alkaloids and summarized the structural elucidation process in detail to provide references for their further research and development.

关 键 词：倍半萜吡啶大环内酯类生物碱 雷公藤属 结构类型 波谱规律 

分 类 号：R284.1[医药卫生—中药学]