广东蛇药对^(131)Ⅰ标记的银环蛇毒在小白鼠膈肌含量的影响  

THE INFLUENCE OF GUANGDONG SNAKEBITE DRUG ON THE DISTRIBUTION OF131 I LABELLED BUNGARUS MULTICINCTUS VENOM IN THE MICE DIAPHRAGMS

作　　者：吴秀荣 曾婉云 沈宝莲 陈克敏 Wu Xiu-rong;Zeng Wan-yun;Shen Bao-lian;Chen Ke-min(Department of pharmacology,Zhongshan medical college)

机构地区：[1]中山医学院药助学教研室

出　　处：《Zoological Research》1981年第S01期121-126,共6页动物学研究（英文）

摘　　要：广东蛇药《原名7118蛇药》对用LD90~100的银环蛇毒、眼镜蛇毒、眼镜王蛇毒及海蛇毒等作皮下注射及用LD50毒量的蝮蛇毒作蝮腔注射而受毒的小白鼠都有非常显著的保护作用(P<0.001)[1]。临床验证中曾用于确诊为毒蛇咬伤的病人308例,其中仅2例蝮蛇伤用过抗蝮蛇毒血清。308例中确诊为银环蛇伤90例、金坏蛇伤2例、眼镜蛇伤56例、蝮蛇伤101、青竹蛇伤30例及其他毒伤29例;除2例银环蛇伤及1例眼镜蛇伤死亡外其他全部治癒;特别是9例银环蛇伤已呼吸停止者,在人工呼吸、适当补水盐、抗菌药等支持疗法下,单用广东蛇药灌胃、对已发生肠麻痺者加用此药注射剂,使7例病人获救,其有效自主呼吸平均在60小时恢复[2]。Guangdong Snakebite Drug (GSD) is a drug formula consisting of two herbs. Passiflora cochinchinensis Spreng and Citrus grandis (L) Osbcck. From our previous experiments (1971-1976) in mice and in clinical trials, the drug proved to be highly effective in treating various snake venoms intoxication. Experiments in 1977 showed that using 131I-Bungarus multicinclus venom (in vitro and in vivo), the average radioactivity in the diaphragms of the control mouse groups was significantly higher than that of the drug-treated groups (P<0.001 and<0.05). Our results suggest that GSD can promote the release of 131I-Bungarotoxin from the cholinorcceptor in the endplates of striated muscles.

关 键 词：呼吸停止 蝮蛇毒 青竹蛇 毒蛇咬伤 临床验证 支持疗法 眼镜蛇毒 抗菌药 

分 类 号：R28[医药卫生—中药学]