抗蝮蛇毒血清的交叉中和作用  

THE CROSS-NEUTRALIZING ACTION OF ANTIVENIN AGAINST AGKISTRODON HALYS PALLAS

作　　者：蒋克贤 郭惠英 陈正伟 龚全元 马颖杰 Jiang Ke-xian;Guo Hui-ying;Chen Zheng-wei;Gong Quan-yuan;Ma Ying-jie(Shanghai Vaccine and Serum Institute,National Ministry of Public Health,People’s Republic of China)

机构地区：[1]卫生部上海生物制品研究所

出　　处：《Zoological Research》1981年第S01期173-175,共3页动物学研究（英文）

摘　　要：用免疫扩散和中和试经法研究了浙江蝮蛇毒马抗血清对我国其他地区的蝮蛇毒和日本蝮蛇毒以及其他蝮亚科蛇毒之间的关系。蛇毒对抗蛇毒血清所得的免疫扩散沉淀线见图A,B。交叉中和试验结果表明,一毫升抗蛇毒血清能分别中和蝮蛇毒素4~5毫克;五步蛇毒素1毫克;烙铁头蛇毒素和竹叶青蛇毒素1.5毫克。(表1、2)。The immunological relationships between horse antivcnom serum to the venom of Agkistrodon halys from Zejiang and venom of Agkistrodon halys from the other parts of China,venom of A,h.blomhoffi from Japan,as well as venoms of other species of Crotalidae were studies by means of immunodiffusion methods and neutralizing tests.A number of precipitating lines were obtained from immunodiffusion method of these selected venoms against the specific antivenin.The results of cross-neutralizing test showed that one ml.of the antivenin could neutralize 4-5 mg of Agkistrodon halys venom,1.0 mg of A.acutus venom,1.5 mg of trimere-surus mucrosquamatus venom,and T.stejnegeri venom respectively.Above results indicate that the venom of Agkistrodon halys from Zejiang contains wider antigen spectrum than those from the other parts of our country.Thereby the venom may be used as a good polyvalent Crotalidae antivenin.

关 键 词：抗蛇毒血清 蝮蛇毒 交叉中和试验 免疫扩散 五步蛇毒 烙铁头蛇毒 中和作用 

分 类 号：R28[医药卫生—中药学]