自然周期体外受精在辅助生殖领域的应用  

Application of natural cycle in vitro fertilization in the reproductive medicine

作　　者：王洋[1] 王霞[1] 龙晓宇[1] 李蓉[1] Wang Yang;Wang Xia;Long Xiaoyu;Li Rong(Reproductive Medical Center,Department of Gynecology and Obstetrics,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院妇产科生殖医学中心,北京100191

出　　处：《中华生殖与避孕杂志》2022年第8期854-858,共5页Chinese Journal of Reproduction and Contraception

基　　金：国家自然科学基金青年科学基金(81801447);北京大学第三医院青年孵育基金(BYSYFY2021048)。

摘　　要：近年,随着治疗理念的转变和经验的积累,损伤小、更接近生理状态的自然周期体外受精(in vitro fertilization,IVF)越来越受到青睐。自然周期IVF不仅可以降低治疗成本,还能有效减少患者来院就诊次数,提高治疗的满意度和依从性。卵泡提前破裂等导致的周期取消率高仍是自然周期IVF面临的主要问题。高龄、子宫内膜容受性下降等也是影响妊娠结局的危险因素。虽自然周期IVF并不降低胚胎染色体异常风险,但产科结局仍优于常规IVF。本文从自然周期IVF的定义出发,就其在辅助生殖治疗过程中的关键技术环节、影响妊娠结局的因素分析和子代安全性及围产结局等方面作一综述。In recent years,with the transforming of therapy conception and accumulation of clinical experience,natural cycle in vitro fertilization(NC-IVF)receives more concerns due to its slight damage and more approach to physiological state.The application of NC-IVF reduces the therapy cost and visiting frequency,at the same time improves the patient satisfaction and compliance.The high cancellation rate of cycles caused by premature rupture of follicles remains the major problem of NC-IVF.Advanced age and reduction of uterine receptivity are also risk factors affecting pregnancy outcomes for NC-IVF.Although NC-IVF can not reduce risks of fetal chromosomal abnormalities,its obstetric outcomes are still better than conventional IVF.In this review,the key techniques of NC-IVF,and risk factors affecting its pregnancy outcomes and offspring safety,as well as its prenatal outcomes were summarized starting from its definition.

关 键 词：受精 体外 胚胎移植 妊娠结局 自然周期 改良自然周期 

分 类 号：R714.8[医药卫生—妇产科学]