腹腔镜下输卵管切开取胚术中应用甲氨蝶呤片及垂体后叶素的疗效分析  

Efficacy of Methotrexate Tablets and Pituitrin in Laparoscopic Tubal Incision and Embryo Extraction

作　　者：徐硕 XU Shuo(Department of Obstetrics and Gynecology,Shangqiu Hospital of Traditional Chinese Medicine,Shangqiu Henan 476000,China)

机构地区：[1]商丘市中医院妇产科,河南商丘476000

出　　处：《临床研究》2022年第11期110-112,共3页Clinical Research

摘　　要：目的探究腹腔镜下输卵管切开取胚术中应用甲氨蝶呤片及垂体后叶素的疗效。方法研究对象选取为2018年4月至2020年10月商丘市中医院的122例输卵管妊娠患者,并通过随机数字表法将研究对象划分为观察组和对照组,各61例。对照组采用腹腔镜下输卵管切开取胚术治疗,观察组则在此基础上,在输卵管系膜处注入甲氨蝶呤片及垂体后叶素治疗。对比两组患者的手术指标,对比两组输卵管通畅率和持续性异位妊娠率。随访1年,对比两组患者的再次异位妊娠率和自然妊娠率。结果两组的手术时间对比,差异无统计学意义(P>0.05);观察组的手术出血量、术后血β-HCG恢复时间显著低于对照组,差异有统计学意义(P<0.05)。观察组患者的输卵管通畅率显著高于对照组,持续性异位妊娠率显著低于对照组,差异均有统计学意义(P<0.05);随访1年内,两组患者再次异位妊娠率、自然妊娠率对比,差异均无统计学意义(P>0.05)。结论腹腔镜下输卵管切开取胚术中应用甲氨蝶呤片及垂体后叶素能够显著减少手术出血量,提高输卵管通畅率,改善了输卵管妊娠患者的临床疗效,但对患者的远期妊娠情况无明显影响。Objective To explore the efficacy of methotrexate and pituitrin in laparoscopic tubal incision and embryo extraction.Methods A total of 122 patients with tubal pregnancy admitted in Shangqiu Hospital of Traditional Chinese Medicine from April 2018 to October 2020 were selected for the study.Patients were randomly divided into observation and control groups by random digital table method,with 61 cases in each group.Laparoscopic tubal incision and embryo extraction was treated in the control group,injection of methotrexate and pituitrin into the mesosalpinx on the basis of laparoscopic tubal incision and embryo extraction was treated at the same time in the observation group.The surgical indexes of the two groups were compared,the patency rate of fallopian tube and the rate of persistent ectopic pregnancy were compared between the two groups.The patients were followed up for 1 year,the rate of re ectopic pregnancy and natural pregnancy were compared between the two groups.Results There was no significant difference in the operation time between the two groups(P>0.05).The amount of surgical bleeding and postoperative bloodβ-HCG recovery time in the observation group were significantly lower than those in the control group,with statistically significant differences(P<0.05).The patency rate of fallopian tube in the observation group was significantly higher than that in the control group,and the rate of persistent ectopic pregnancy was significantly lower than that in the control group,with statistically significant differences(P<0.05);There were no significant differences in the rate of re ectopic pregnancy and natural pregnancy between the two groups within one year of follow-up(P>0.05).Conclusion The application of methotrexate and pituitrin in laparoscopic tubal incision and embryo extraction can significantly reduce the amount of surgical bleeding,improve the patency rate of fallopian tube and improve the clinical efficacy of patients with fallopian tube pregnancy,but it has no significant effect on the long-ter

关 键 词：输卵管妊娠 腹腔镜 输卵管切开取胚术 甲氨蝶呤片 垂体后叶素 

分 类 号：R713[医药卫生—妇产科学]