稳心颗粒联合倍他乐克对不稳定型心绞痛的治疗效果影响  

The Therapeutic Effect of Wenxin Particles Combined with Metoprolol on Unstable Angina

作　　者：段娜娜[1] 宋溢娟 秦均匀 康艳丽[1] DUAN Nana;SONG Yijuan;QIN Junyun;KANG Yanli(Department of Geriatrics,The First Affiliated Hospital of Henan University of Science and Technology,Luoyang Henan 471000,China)

机构地区：[1]河南科技大学第一附属医院老年医学科,河南洛阳471000

出　　处：《临床研究》2022年第11期120-123,共4页Clinical Research

摘　　要：目的分析不稳定型心绞痛病患开展倍他乐克及稳心颗粒治疗的作用。方法选择河南科技大学第一附属医院2019年1月至2021年6月收治的96例不稳定型心绞痛病患。分组方式选择随机摸红蓝球方式,其中常规组(48例)摸蓝球,试验组(48例)摸红球,将倍他乐克应用于常规组病患中,将倍他乐克及稳心颗粒应用于试验组病患中。针对每组病患各时期血脂水平、炎性因子水平、血液流变学指标水平、运动耐力、心绞痛发作情况及治疗效果进行比较。结果两组用药后低密度脂蛋白胆固醇、总胆固醇及甘油三酯水平相较用药前低,高密度脂蛋白胆固醇水平相较于用药前高;用药后试验组病患低密度脂蛋白胆固醇、总胆固醇及甘油三酯水平相较常规组低,高密度脂蛋白胆固醇水平相较于常规组高,差异有统计学意义(P<0.05)。两组用药后白细胞介素-6、白细胞介素-18及C反应蛋白水平相较用药前低,用药后试验组病患白细胞介素-6、白细胞介素-18及C反应蛋白相较于常规组低,差异有统计学意义(P<0.05)。两组用药后血浆黏度、纤维蛋白原、全血低切黏度、全血高切黏度水平相较于用药前低,用药后试验组病患血浆黏度、纤维蛋白原、全血低切黏度、全血高切黏度水平相较于常规组低,差异有统计学意义(P<0.05)。两组用药后6 min步行距离相较用药前长,用药后试验组病患6 min步行距离相较常规组长,差异有统计学意义(P<0.05)。两组用药后病患心绞痛发作次数相较用药前少,持续时间相较用药前短;用药后试验组病患发作次数相较试验组少,持续时间相较常规组短,差异有统计学意义(P<0.05)。试验组与常规组病患治疗有效率依次是95.83%、81.25%,差异有统计学意义(P<0.05)。结论不稳定型心绞痛病患开展倍他乐克及稳心颗粒治疗,能够降低血脂及炎性因子水平,改善血液流变学指标,提高运动耐力,Objective To analyze the effect of Wenxin particle combined with Metoprolol in unstable angina pactoris patients.Methods A total of 96 unstable angina pactoris patients treated in our hospital from January 2019 to June 2021 were selected.According to the ball-touching method,patients were divided into routine group(N=48,blue ball)and trial group(N=48,red ball).Metoprolol was applied in the routine group;Wenxin particle combined with metoprolol was applied in the trial group.The blood lipid,inflammatory factors,hemorheology indexes,exercise tolerance,angina attack and treatment effect were compared between two groups.Results After medication,low-density lipoprotein cholesterol,total cholesterol and triglyceride contents in two groups were lower than before;the high-density lipoprotein-cholesterol contents in two groups were higher than before.After medication,the low-density lipoprotein cholesterol,total cholesterol and triglyceride contents in the trial group were even lower than routine group;The high-density lipoprotein-cholesterol content in the trial group was even higher than routine group,the differences were statistically significant(P<0.05);After medication,interleukin-6,interleukin-18 and C-reactive protein levels in two groups were lower than before;After medication,interleukin-6,interleukin-18 and C-reactive protein levels in the trial group were even lower than routine group,the differences were statistically significant(P<0.05);After medication,plasma viscosity,fibrinogen,whole blood low-shear viscosity,whole blood high-shear viscosity levels in two groups were lower than before;After medication,plasma viscosity,fibrinogen,whole blood low-shear viscosity,whole blood high-shear viscosity levels in the trial group were even lower than routine group,the differences were statistically significant(P<0.05);After medication,6-minute walk distance in two groups were longer than before;After medication,6-minute walk distance in the trial group was even longer than routine group,the difference was statisticall

关 键 词：不稳定型心绞痛 倍他乐克 稳心颗粒 炎性因子 血液流变学 

分 类 号：R541.4[医药卫生—心血管疾病]