通鼻消涕颗粒对慢性鼻窦炎鼻黏膜功能的影响  

Effects of Tongbixiaoti Granules on the Function of Nasal Mucosa in Chronic Rhinosinusitis

作　　者：李治金 张玲 杨佳凤 李潞璇 查入宁 黄春江 LI Zhijin;ZHANG Ling;YANG Jiafeng;LI Luxuan;ZHA Runing;HUANG Chunjiang(Yunnan University of Chinese Medicine,Kunming 650500,China;The First Affiliated Hospital of Yunnan University of Chinese Medicine,Kunming 650021,China;Chengdu University of Traditional Chinese Medicine,Chengdu 610000,China)

机构地区：[1]云南中医药大学,云南昆明650500 [2]云南中医药大学第一附属医院,云南昆明650021 [3]成都中医药大学,四川成都610000

出　　处：《云南中医学院学报》2022年第2期1-4,共4页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：云南省科学技术厅-云南中医药大学应用基础研究联合专项资金面上项目(202101AZ070001-279)。

摘　　要：目的对医院制剂通鼻消涕颗粒对慢性鼻窦炎鼻黏膜功能是否有调控作用进行临床研究。方法收集慢性鼻窦炎不伴鼻息肉患者,采用单盲方法随机将患者分为治疗组(通鼻消涕颗粒组)和对照组(克拉霉素片组)。分别给予口服通鼻消涕颗粒和克拉霉素片治疗4周,并对治疗前、治疗2周后、治疗4周后的患者进行糖精试验、鼻部症状VAS评分与鼻内镜Lund Kennedy评分。并采用t检验统计分析。比较服药前、服药后的评分变化。结果VAS评分提示:治疗组中,治疗2周后、治疗4周后与治疗前相比差异均有统计学意义(P<0.05),对照组在治疗后的各个阶段与治疗前相比均无明显差异(P>0.05)。Lund Kennedy评分提示:治疗组在治疗2周后与治疗前无明显差异,但在治疗4周后有明显改善(P<0.05),对照组则在治疗后各个阶段无明显变化(P>0.05)。糖精试验提示2组在治疗后2周患者糖精清除时间差异无统计学意义(P>0.05),但治疗组在治疗4周后患者糖精清除时间低于对照组(P<0.05)。结论通鼻消涕颗粒对慢性鼻窦炎的鼻黏膜形态与传输功能有明显改善作用,可以促进鼻黏膜纤毛功能的恢复,并优于克拉霉素片组,且无毒副作用,值得临床上推广应用。Objective To investigate the effect of Tongbixiaoti granules on the function of CRSsNP nasal mucosa.Methods Patients with chronic rhinosinusitis without nasal polyps were collected,and the patients were randomly divided into treatment group(Tongbixiaoti granules group)and control group(clarithromycin tablet group)by single blind method.They were respectively treated with Tongbixiaoti granules and clarithromycin tablets for 4 weeks.The VAS score of symptoms,Saccharin test and Lund Kennedy score of nasal endoscopy were observed before and 2 weeks and 4 weeks after treatment.T-test was used for statistical analysis to compare the score changes before and after medication.Rusults The VAS score of Tongbixiaoti granules group was significantly improved after 2 weeks and 4 weeks of treatment(P<0.05).The clarithromycin tablet group had no significant improvement after 2 weeks and 4 weeks of treatment(P>0.05).Lund Kennedy score showed that there was no significant difference between in the Tongbixiaoti granules group at 2 weeks of treatment,but it was significantly improved after 4 weeks of treatment(P<0.05).Clarithromycin tablets group was not significantly changed(P>0.05).The saccharin test showed that there was no significant improvement in the saccharin clearance time between two groups after 2 weeks of treatment(P>0.05),but the saccharin clearance time of Tongbixiaoti granules group after 4 weeks of treatment was lower than that of clarithromycin tablet group(P<0.05).Concllusion Tongbixiaonti granules can significantly improve the shape and transmission function of the nasal mucosa on CRSsNP,and can promote the recovery of nasal mucociliary function.It is better than clarithromycin tablet group,and has no obvious toxic and side effects,which is worthy of popularization and application.

关 键 词：慢性鼻窦炎 通鼻消涕颗粒 黏液纤毛传输系统 

分 类 号：R276.1[医药卫生—中医五官科学]