祁白术对脾气虚模型大鼠的治疗作用  

Therapeutic Effect of Atractylodes macrocephala Koidz Grown in Qimen on Rat Model with Spleen Qi Deficiency

作　　者：葛廷雨 姚兆敏 李颖 陈月 张苗苗 仰忠华 汪电雷 GE Tingyu;YAO Zhaomin;LI Ying;CHEN Yue;ZHANG Miaomiao;YANG Zhonghua;WANG Dianlei(College of Pharmacy,Anhui University of Chinese Medicine,Hefei 230012,China;First Clinical Medical College,Anhui University of Chinese Medicine,Hefei 230601,China;Anhui Xianyushan Agricultural Technology Co.Ltd.,Huangshan 245000,China)

机构地区：[1]安徽中医药大学药学院,安徽合肥230012 [2]安徽中医药大学第一临床医学院,安徽合肥230601 [3]安徽仙寓山农业科技有限公司,安徽黄山245000

出　　处：《云南中医学院学报》2022年第2期59-64,69,共7页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：安徽高校科研平台创新团队(2016HZ23);安徽省重点研究与开发计划项目(201904a07020061)。

摘　　要：目的研究祁白术对脾气虚模型大鼠的治疗作用。方法采用劳倦伤脾加限制饮食的方法建立脾气虚模型大鼠,通过观察不同产地不同剂量的白术汤剂治疗模型大鼠1周后的血清D-木糖含量、胃泌素、胃动素、胃蛋白酶、胰蛋白酶、白细胞介素-6、生长抑制素、脾和胸腺指数的影响。结果与对照组相比,模型组大鼠的体质量显著下降并且其血清D-木糖含量、胃泌素、胃蛋白酶、胰蛋白酶、脾和胸腺指数水平明显降低,但是白细胞介素-6和生长激素抑制素的水平显著升高。给予模型组大鼠白术汤剂和丹弗胃尔康颗粒后,给药组指标与模型组相反。结论给予祁白术的模型组大鼠的检测指标变化更为明显。不同产地白术的治疗效果也不同,实验结果表明,祁白术对脾气虚大鼠有治疗作用。Objective To study the therapeutic effect of Atractylodes macrocephala Koidz grown in Qimen(Qi Baizhu)on rat model with spleen qi deficiency.Methods The rat model with spleen qi deficiency was established with fatigue injury and restricted diet.The effects of different doses of A.macrocephala Koidz decoction from different areas on serum D-xylose content,gastrin,motilin,pepsin,trypsin,interleukin-6,growth inhibin,spleen and thymus index of spleen and thymus deficiency model rats were observed.Results Compared with control group,the weight of rats in the model group decreased significantly and the levels of D-xylose content,serum gastrin,pepsase,trypsin,spleen and thymus indexes of model rats were significantly lower than those in the control rats.But the levels of interleukin-6 and somatostatin were significantly elevated.After giving A.macrocephala Koidz decoction and Danfu Weierkang granule to the model group,the index of the administration group was opposite to that of the model group.Conclusion The changes of detection indexes in the model group treated with Qi Baizhu were more obvious.The above results indicated that the therapeutic effects of A.macrocephala Koidz from different origins were different.The experimental results showed that Qi Baizhu had therapeutic effect on rats with spleen qi deficiency.

关 键 词：祁白术 白术 脾气虚 D-木糖 汤剂 治疗作用 

分 类 号：R285.5[医药卫生—中药学]