富马酸替诺福韦二吡呋酯片治疗HBV感染孕妇及阻断母婴传播的效果  

Effect of Tenofovir Disoproxil Fumarate Tablets on Pregnant Women with HBV Infection and Blocking Mother-to-child Transmission

作　　者：黄熙琳 HUANG Xilin(Shenzhen People’s Hospital,Shenzhen 518000,China)

机构地区：[1]深圳市人民医院,广东深圳

出　　处：《中外医学研究》2022年第25期21-24,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨富马酸替诺福韦二吡呋酯片(TDF)治疗乙型肝炎病毒(HBV)感染孕妇及阻断母婴传播的效果。方法:回顾性分析2020年1-12月深圳市人民医院收治的82例HBV感染孕妇,按治疗方法将入选者分为常规保肝治疗组(常规保肝治疗,40例)、TDF治疗组(TDF治疗,42例)。比较两组谷丙转氨酶(ALT)复常率及乙型肝炎病毒-脱氧核糖核酸(HBV-DNA)转阴率、肝功能指标、婴儿出生后乙型肝炎表面抗体(HBsAb)、乙型肝炎表面抗原(HBsAg)阳性率及不良反应发生情况。结果:TDF治疗组不同孕周ALT复常率及HBV-DNA转阴率均高于常规保肝治疗组(P<0.05);分娩后6个月,TDF治疗组ALT、门冬氨酸氨基转移酶(AST)、总胆血红素(TBIL)水平低于常规保肝治疗组(P<0.05);TDF治疗组婴儿出生时、出生后6个月HBsAb阳性率高于常规保肝治疗组;出生后6个月,TDF治疗组婴儿HBsAg阳性率低于常规保肝治疗组(P<0.05);TDF治疗组不良反应发生率(4.76%)低于常规保肝治疗组(20.00%)(P<0.05)。结论:TDF用于治疗HBV感染孕妇,可有效抑制病毒复制,提高HBV-DNA转阴率,从而改善患者的肝功能,促进ALT复常,同时能阻断HBV母婴垂直传播,且不良反应少,安全性较高。Objective:To investigate the effect of Tenofovir Disoproxil Fumarate Tablets (TDF) in the treatment of hepatitis B virus (HBV) infected pregnant women and the effect of blocking mother-to-child transmission.Method:A retrospective analysis of 82 pregnant women with HBV infection admitted in Shenzhen People’s Hospital from January to December 2020 was conducted.According to the treatment method,the participants were divided into conventional liver protection treatment group (conventional liver protection treatment,40 cases) and TDF treatment group (TDF treatment,42 cases).The alanine aminotransferase (ALT) normalization rate and hepatitis B virus deoxyribonucleic acid (HBV-DNA) negative rate,liver function indexes,positive rate of hepatitis B surface antibody (HBsAb),hepatitis B virus surface antigen (HBsAg) after birth and the incidence of adverse reactions were compared between the two groups.Result:After treatment,the ALT normalization rate and the negative conversion rate of HBV-DNA in TDF treatment group were higher than those in conventional liver protection treatment group (P<0.05).Six months after delivery,the levels of ALT,aspartate aminotransferase (AST),total bilirubin (TBIL) in TDF treatment group were lower than those in conventional liver protection treatment group (P<0.05).The positive rate of HBsAb at birth and 6 months after birth of infants in TDF treatment group was higher than that in conventional liver protection treatment group,the positive rate of HBsAg 6 months after birth of infants in TDF treatment group was lower than that in conventional liver protection treatment group (P<0.05).The incidence of adverse reactions in TDF treatment group (4.76%) was lower than that in conventional liver protection treatment group (20.00%) (P<0.05).Conclusion:TDF in the treatment of HBV infected pregnant women can effectively inhibit virus replication and improve the negative rate of HBV-DNA,so as to improve the liver function of patients,promote the normalization of ALT,and block the vertical transmissio

关 键 词：富马酸替诺福韦二吡呋酯片 乙型肝炎病毒 孕妇 谷丙转氨酶 不良反应 

分 类 号：R714.251[医药卫生—妇产科学]