前列地尔联合丁苯酞治疗急性重度一氧化碳中毒患者的心肌和脑组织疗效分析  

Efficacy of prodil combined with butylphthalide on myocardial and brain tissues in patients with acute severe carbon monoxide poisoning

作　　者：牛净姿 刘鹏飞[1] 李敬[1] 刘永建[1] Niu Jingzi;Liu Pengfei;Li Jing;Liu Yongjian(Department of Critical Care Medicine,Harrison International Peace Hospital Affiliated to Hebei Medical University,Hengshui 053000,Hebei Province,China)

机构地区：[1]河北医科大学哈励逊国际和平医院重症监护病房,衡水053000

出　　处：《中华老年心脑血管病杂志》2022年第9期961-964,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：河北省医学科学研究重点课题(20200405)。

摘　　要：目的 探讨前列地尔联合丁苯酞治疗急性重度一氧化碳中毒(ASCOP)患者的心肌和脑组织的疗效。方法 选择ASCOP患者186例,随机分为观察组93例和常规组93例。常规组给予常规对症处理,观察组加用前列地尔注射液联合丁苯酞胶囊,计算中性粒细胞与淋巴细胞比值(NLR)和单核细胞与HDL-C比值(MHR)。监测治疗前后脑电双频谱指数(BIS)。结果 观察组昏迷时间、清醒时间明显短于常规组,治疗后总有效率明显高于常规组(P<0.05,P<0.01)。与治疗前比较,2组治疗后NLR、MHR明显降低,BIS明显升高(P<0.05)。观察组治疗后NLR、MHR明显低于常规组,BIS明显高于常规组,差异有统计学意义(P<0.01)。观察组不良事件发生率明显低于常规组(6.45%vs 16.13%,P=0.031)。BIS与昏迷时间呈负相关(r=-0.646,P=0.004),NLR、MHR与昏迷时间呈正相关(r=0.720,P=0.001;r=0.756,P=0.001)。结论 前列地尔联合丁苯酞治疗ASCOP,减轻了脑组织和心肌组织的损伤,降低不良事件,提高ASCOP生活能力。Objective To explore the efficacy of prodil combined with butylphthalide in ASCOP.Methods A total of 186 ASCOP patients admitted to our hospital were recruited in this study.They were randomly divided into conventional treatment group(n=93) and observation group(n=93).The patients from the conventional treatment group were given routine symptomatic treatment, and those of the observation group were given additional prodil injection combined with butylphthalide capsule.Then NLR and MHR were calculated.BIS values were monitored before and after treatment.Results The observation group had significantly shorter coma time and awake time, and obtained higher total efficacy than the conventional treatment group(P<0.05,P<0.01).After treatment, NLR and MHR were significantly decreased, and BIS value was increased obviously in both groups(P<0.05).The NLR and MHR were notably lower, and BIS value were remarkably higher in the observation group than the conventional treatment group(P<0.01).The incidence of adverse events in the observed group was lower than that in the conventional treatment group(6.45% vs 16.13%,P=0.031).BIS value was negatively correlated with coma time(r=-0.646,P=0.004),and NLR and MHR were positively with coma time(r=0.720,P=0.001;r=0.756,P=0.001).Conclusion Prodil combined with butylphthalide can be used to treat ASCOP,by reducing the damages in brain and myocardial tissues and decreasing occurrence of adverse events, and improve the living ability of ASCOP patients.

关 键 词：前列地尔 一氧化碳中毒 单核细胞 胆固醇 HDL 

分 类 号：R595.1[医药卫生—内科学]