阿仑膦酸钠致食管炎  

Esophagitis due to alendronate sodium

作　　者：陈彦豪 周晓滨 范爽[1] 王晓东[1] 段立伟[1] Chen Yanhao;Zhou Xiaobin;Fan Shuang;Wang Xiaodong;Duan Liwei(Gastroenterology and Digestive Endoscopy Center,the Second Hospital of Jilin University,Changchun 130041,China)

机构地区：[1]吉林大学第二医院胃肠内科及消化内镜中心,长春130041

出　　处：《药物不良反应杂志》2022年第9期490-491,共2页Adverse Drug Reactions Journal

摘　　要：1例62岁女性骨质疏松患者口服阿仑膦酸钠70 mg、1次/周(早餐前30 min饮足量水顿服,服用时及服用后均保持立位)。用药3次后出现吞咽时胸骨后刺痛,偶有反酸及上腹部隐痛。胃镜检查示食管距门齿20~37 cm处可见多发浅溃疡,表面覆黄白苔。考虑为食管炎,可能与阿仑膦酸钠有关。停用该药,给予抑酸、修复黏膜和适当补液治疗,并予全流食。2 d后胸骨后刺痛减轻;7 d后胸骨后刺痛较前明显减轻,反酸及上腹部隐痛消失;1个月后吞咽时胸骨后刺痛消失。A 62‑year‑old female osteoporosis patient received alendronate sodium 70 mg orally once a week(taking the drug 30 minutes before breakfast with plenty of water and keeping upright during and after taking drug for a while).After taking the drug for 3 times,the patient developed retrosternal pain on swallowing with occasional acid aversion and epigastric dull pain.Gastroscopy showed multiple shallow ulcers,with yellow and white fur on the surface,in the esophagus 20 cm to 37 cm from the incisors.Esopha‑gitis was considered,which might be related to alendronate sodium.Alendronate was stopped,and the treat‑ments of acid suppression,mucosal repair,proper rehydration,and total liquid intake were given.Two days later,the stabbing pain behind the sternum was relieved;7 days later,the pain was obviously relieved and symptoms of the acid aversion and epigastric dull pain disappeared;1 month later,the retrosternal pain on swallowing disappeared.

关 键 词：溃疡 药物相关副作用和不良反应 阿仑膦酸 

分 类 号：R969[医药卫生—药理学]