多羧酸受体化合物的差异性结构构筑与合成线路优化  

Differential structure construction and synthetic optimization of polycarboxyl-acid receptors

作　　者：成昭[1] 郑蕾[1] 徐玥[1] 何昊[1] CHENG Zhao;ZHENG Lei;XU Yue;HE Hao(School of Pharmacy,Xi'an Medical University,Xi'an 710021,China)

机构地区：[1]西安医学院药学院,陕西西安710021

出　　处：《化学工程师》2022年第10期12-16,21,共6页Chemical Engineer

基　　金：陕西省自然科学基础研究计划(2022JM-542)。

摘　　要：分别以苯胺、邻氨基酚、邻苯二胺作为起始原料,进行多羧酸受体分子结构的差异性构筑。构建柔性羧酸链作为多齿受体对目标物的结合位点,设计一系列结构相似而结合位点有差异的二羧酸、邻位三羧酸与邻位四羧酸多齿受体,同时,通过给电子基团-CH3、吸电子基团-NO2的引入,调节多羧酸受体与目标物结合程度的强弱,合成得到多羧酸受体化合物T6~T10。结合IR、1H NMR、HRMS-ESI等手段进行多羧酸受体T6~T10的分子结构表征,进一步优化反应条件、提高缩合反应收率,为阐明多羧酸受体进行目标物识别、结合的可能作用机制提供了研究基础。By incorporating aniline,o-phenylenediamine and m-phenylenediamine as the initial materials,differential structure design on polycarboxyl-acid receptors was constructed.Two,ortho-three and ortho-four flexible chains of carboxylic acid were introduced into the receptors as the recognition sites,furthermore,electron-donating methyl group and electron-withdrawing nitro group were introduced to alter the affinity of receptors towards the target,resulting in a series of polydentate receptors T6~T10 with similar structures and only difference in the recognition sites.Structures of the synthesized polycarboxyl-acid receptors T6~T10 were characterized by IR,1H NMR and HRMS-ESI,and the synthetic method was optimized to improve the final yield of the condensation reaction,providing basis for a better understanding of the mechanism of the polycarboxyl acid receptors-target recognition.

关 键 词：结构设计 合成 多羧酸类受体 包合空腔 

分 类 号：O622.5[理学—有机化学]