琥珀酸脱氢酶抑制剂类杀菌剂抗性研究进展  

Research progress of the resistance to succinate dehydrogenase inhibitors

作　　者：毛玉帅 段亚冰 周明国[1,2] MAO Yushuai;DUAN Yabing;ZHOU Mingguo(Department of Pesticide Sciences,College of Plant Protection,Nanjing Agricultural University,Nanjing 210095,China;Research Center for Pesticide Resistance,Nanjing Agricultural University,Nanjing 210095,China)

机构地区：[1]南京农业大学植物保护学院农药系,南京210095 [2]南京农业大学农药抗性与治理技术研究中心,南京210095

出　　处：《农药学学报》2022年第5期937-948,共12页Chinese Journal of Pesticide Science

基　　金：国家重点研发计划(2016YFD0200500).

摘　　要：作用于琥珀酸脱氢酶复合体的新型杀菌剂-琥珀酸脱氢酶抑制剂(succinate dehydrogenase inhibitors,SDHIs)已逐步成为继Qo位点呼吸抑制剂类(QoIs)和麦角甾醇生物合成抑制剂类(EBIs)杀菌剂之后的世界第3大类杀菌剂。近年来,SDHIs杀菌剂的市场占有份额逐年增加,新品种不断涌现,在植物病害化学防治中发挥着重要作用。然而,由于该类杀菌剂作用位点单一,抗药性已成为制约该类杀菌剂创制发展与科学应用的重要科学问题。本综述归纳了琥珀酸脱氢酶抑制剂类杀菌剂的开发、品种、抗性发生发展、抗性分子机制与应用现状,并结合作者研究团队的最新研究成果对其靶标生物学及应用技术研究进行了总结,以期为更高活性的SDHIs杀菌剂创制和应用提供参考。Succinate dehydrogenase inhibitors(SDHIs),targeting succinate dehydrogenase complex,have gradually become the third largest group of fungicides in the world after quinone outside inhibitors(QoIs)and ergosterol biosynthesis inhibitors(EBIs).In recent years,the market share of SDHIs is increasing yearly,and new members are emerging,playing a vital role in the chemical control of plant diseases.However,due to the single action site of these fungicides,fungicide resistance has become a key scientific issue that restricts the development and scientific application of these fungicides.In this paper,the development,products,occurrence and development of resistance,molecular mechanism and application status of SDHIs were reviewed.Together with the latest research achievements from the author's laboratory,the research on target biology and application technology was summarized,to provide references for the innovation and application of higher activity SDHIs.

关 键 词：琥珀酸脱氢酶抑制剂 杀菌剂靶标 抗药性 植物病害 防治效果 

分 类 号：TQ450.13[化学工程—农药化工] S481.4[农业科学—农药学]