手性农药选择性生物活性与毒性效应研究进展  

Research progress on the stereoselective bioactivity and toxicity of chiral pesticides

作　　者：郭浩铭 魏一木 刘雪科 刘东晖 王鹏[1] 周志强[1] GUO Haoming;WEI Yimu;LIU Xueke;LIU Donghui;WANG Peng;ZHOU Zhiqiang(Innovation Center of Pesticide Research,College of Science,China Agricultural University,Beijing 100193,China)

机构地区：[1]中国农业大学理学院农药创新研究中心,北京100193

出　　处：《农药学学报》2022年第5期1108-1124,共17页Chinese Journal of Pesticide Science

基　　金：中国农业大学2115人才培育发展支持计划.

摘　　要：手性农药因对映体在生物活性、毒性、环境行为等方面的差异性而备受关注,充分了解对映体的立体选择性对开发高活性农药及减量使用具有重要意义。本文聚焦手性农药对映体的立体选择性效应,系统地调研了对映体生物活性和毒性选择性差异,并进行了分类梳理,重点综述了手性农药对映体的生物活性及毒性和环境风险的差异性,阐述了手性农药对非靶标生物造成的氧化应激、内分泌干扰等慢性毒性,同时关注选择性的规律与机制,为环境友好型高效手性农药的开发、手性农药的风险评估及管理、手性农药对映体立体选择性机制研究提供参考。Chiral pesticides have attracted much attention due to enantiomeric differences in biological activity,toxicity and environmental behavior.It is significant to understand the stereoselectivity of enantiomers for developing highly active pesticides and reducing dosage.This review focus on the stereoselective effects of enantiomers of chiral pesticides,thoroughly investigated the enantioselective biological activitiy and toxicity selectivity,and sort it out,the bioactivity,toxicity and environmental risk of enantiomers of chiral pesticides were reviewed.This review described the chronic toxicity of chiral pesticides to non-target organisms,such as oxidative stress and endocrine disruption,and pay attention to the rules and mechanisms of stereoselectivity,in order to provide reference for the development of environmentally friendly and efficient chiral pesticides,the risk assessment and management of chiral pesticides,and the stereoselectivity mechanism of chiral pesticides.

关 键 词：手性农药 对映体 生物活性 立体选择性 毒性效应 

分 类 号：TQ450.2[化学工程—农药化工]