中性粒细胞胞外诱捕网在系统性红斑狼疮相关间质性肺病中的作用  

Role of neutrophil extracellular traps in systemic lupus erythematosus-associated interstitial lung disease

作　　者：孙宇石 杨森 林慧庆[1] SUN Yu-Shi;YANG Sen;LIN Hui-Qing(Department of Thoracic Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,China;First Clinical College of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院胸外科,武汉430060 [2]武汉大学第一临床学院,武汉430060

出　　处：《中华老年多器官疾病杂志》2022年第9期699-703,共5页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：国家自然科学基金面上项目(82170106);中国器官移植发展基金(2020HX0011);中央高校基本科研业务费专项资金(2042021kf1038)。

摘　　要：中性粒细胞参与病原体清除与早期炎症反应,是免疫系统的重要组成部分。但近年来越来越多的研究表明,中性粒细胞通过形成中性粒细胞胞外诱捕网(NETs)介导炎症反应并促进纤维化的形成,在自身免疫性疾病和间质性肺病(ILD)的发病机制中的作用逐渐受到重视。本文首先介绍NETs的结构、功能和形成过程,并结合NETs在其他自身免疫病中的作用,总结NETs参与系统性红斑狼疮(SLE)相关ILD针对NETs的发病机制,最后提出了自身免疫性疾病相关ILD针对NETs的潜在治疗靶点。Neutrophils,involved in pathogen clearance and early inflammatory responses,are an important part of the immune system.However,in recent years,more and more studies have shown that neutrophils mediate inflammatory responses and promote fibrosis by forming neutrophil extracellular traps(NETs),and their role in the pathogenesis of autoimmune diseases and pulmonary interstitial fibrosis has been attracting attention.The review first introduces the structures,functions,and formation of NETs,then summarizes their role in systemic lupus erythematosus-associated interstitial lung disease(SLE-ILD)in reference to the pathogenesis of other autoimmune diseases,and finally proposes prospective therapeutic targets of NETs in autoimmune disease-related ILD.

关 键 词：中性粒细胞胞外诱捕网 系统性红斑狼疮 间质性肺疾病 

分 类 号：R563.13[医药卫生—呼吸系统]