基于定量CT的中国健康成年女性腰椎骨密度正常参考值及地区差异  

Reference value of lumbar spine bone mineral density and regional differences based on quantitative CT examination in healthy adult female in China

作　　者：金鹰 赵凯平[2] 瞿建 杜霞 李永丽[5] 陈爽[6] 吴艳[7] 吴春维 洪国斌[9] 陆勇[10] 张玉琴 马骁[12] 陆靖 肖喜刚[14] 龚向阳[15] 杨泽宏[16] 陈伟 安苗苗 王子云 聂四平 吕英茹[6] 高剑波[7] 李绍林[9] 李跃华 曾强[18] 程晓光[19] 冉利梅 Ying Jin;Kaiping Zhao;Jian Qu;Xia Du;Yongli Li;Shuang Chen;Yan Wu;Chunwei Wu;Guobin Hong;Yong Lu;Yuqin Zhang;Xiao Ma;Jing Lu;Xigang Xiao;Xiangyang Gong;Zehong Yang;Wei Chen;Miaomiao An;Ziyun Wang;Siping Nie;LüYingru;Jianbo Gao;Shaolin Li;Yuehua Li;Qiang Zeng;Xiaoguang Cheng;Limei Ran(School of Public Health,Guizhou Medical University,Guiyang 550025,China;Department of Medical Record Management and Statistics,Beijing Jishuitan Hospital,Beijing 100035,China;Department of Health Center,Yijishan Hospital of Wannan Medical College,Wuhu 241001,China;Department of Radiology,the Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China;Department of Health Management,Henan Procincial People′s Hospital,Zhengzhou 450003,China;Department of Radiology,the Affiliated Huashan Hospital of Fudan University,Shanghai 200040,China;Department of Radiology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Health Management Center of Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China;Department of Radiology,the Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai 519000,China;Department of Radiology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Ningbo Medical Center Li Huili Hospital,Ningbo 315040,China;Physical Examination Center of China-Japan Friendship Hospital,Beijing 100029,China;Department of Imaging,the Sixth People′s Hospital Affiliated to the Medical College of Shanghai Jiaotong University,Shanghai 200233,China;Department of Radiology,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China;Department of Radiology,Zhejiang People′s Hospital,Hangzhou 310014,China;Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,China;Department of Radiology,the First Affiliated Hospital of Army Medical University,Chongqing 400038,China;Institute of Health Management,Second Medical Center,PLA General Hospital,Beijing 100853,China;Department of Radiology,Beijing Jishuitan Hospital,Beijing 1

机构地区：[1]贵州医科大学公共卫生学院,贵阳550025 [2]北京积水潭医院病案统计室,北京100035 [3]皖南医学院戈矶山医院健康管理中心,芜湖241001 [4]贵州医科大学附属医院放射科,贵阳550004 [5]河南省人民医院健康管理中心,郑州450003 [6]复旦大学华山医院放射科,上海200040 [7]郑州大学第一附属医院放射科,郑州450052 [8]贵州医科大学附属医院健康管理中心,贵阳550004 [9]中山大学附属第五医院放射科,珠海519000 [10]上海交通大学医学院附属瑞金医院放射科,上海200025 [11]宁波医学中心李惠利医院放射科,宁波315040 [12]中日友好医院体检中心,北京100029 [13]上海交通大学医学院附属第六人民医院影像科,上海200233 [14]哈尔滨医科大学附属第一医院放射科,哈尔滨150001 [15]浙江省人民医院放射科,杭州310014 [16]中山大学孙逸仙纪念医院放射科,广州510120 [17]陆军军医大学第一附属医院放射科,重庆400038 [18]解放军总医院第二医学中心健康管理研究院,北京100853 [19]北京积水潭医院放射科,北京100035

出　　处：《中华健康管理学杂志》2022年第9期610-615,共6页Chinese Journal of Health Management

摘　　要：目的建立中国健康成年女性人群定量CT(QCT)腰椎骨密度(BMD)正常参考值, 并探究其地区差异。方法收集中国健康定量CT大数据项目符合纳入标准的健康女性人群35 431例。采用美国 Mindways 的定量CT系统, 测量L1、L2椎体中心层面BMD, 取平均值。单因素方差分析比较不同年龄段之间和不同地区之间的女性腰椎BMD差异。按10岁年龄间隔, 同年龄段不同地区之间两两比较。结果中国健康成年女性人群峰值骨密度出现在20~29岁年龄段[东北(183.01±24.58)mg/cm^(3)、华北(188.93±24.80)mg/cm^(3)、华东(187.54±27.71)mg/cm^(3)、华南(186.22±33.72)mg/cm^(3)、华中(176.33±24.91)mg/cm^(3)、西南(182.25±28.00)mg/cm^(3)], 随后随年龄增加呈下降趋势。各地区BMD水平随着年龄增长而降低, 70岁以前, 华中和西南地区BMD[(176.23±24.91)至(90.38±28.12)mg/cm^(3), (182.25±28.00)至(88.55±25.68)mg/cm^(3)]始终处于较低水平, 低于东北[(183.01±24.58)至(99.69±27.85)mg/cm^(3))、华北(188.93±24.80)至(95.89±26.12)mg/cm^(3)]、华东[(187.54±27.71)至(95.65±27.86)mg/cm^(3)]地区(P<0.01);≥70岁各地区BMD趋于一致(P>0.05)。华中和西南地区在40~60岁年龄段BMD值接近(P>0.05), ≥60岁各地区BMD均低于骨量异常值(均P<0.05)。≥50岁女性西南地区骨质疏松检出率最高(25.65%), 华北地区最低(17.30%)。结论建立了中国健康女性人群的QCT骨密度参考值数据库, 西南地区BMD值最低, 华南地区BMD值最高。Objective To establish the normal reference value of lumbar bone mineral density(BMD)under quantitative CT(QCT)in Chinese healthy adult females and to explore the regional differences.Methods Total of 35431 healthy women who met the inclusion criteria of Chinese health quantitative CT big data program were selected in this study.The BMD of the central plane of L1 and L2 vertebrae was measured by Mindways′s QCT system,and the mean value was taken.One-way analysis of variance was used to compare the BMD differences of lumbar vertebrae in women of different ages and regions.The subjects were grouped by an age interval of 10 years,and the level of BMD in different regions of the same age group were compaired.Results The peak BMD of Chinese healthy adult women appeared in the age group of 20-29 years(Northeast China(183.01±24.58)mg/cm^(3),North China(188.93±24.80)mg/cm^(3),East China(187.54±27.71)mg/cm^(3),South China(186.22±33.72)mg/cm^(3),Central China(176.33±24.91)mg/cm^(3),Southwest China(182.25±28.00)mg/cm^(3)),and then it decreased with age.The level of BMD in different regions decreased with the age.Before the age of 70 years,BMD in Central and Southwest China was always at a low level((176.23±24.91)to(90.38±28.12)mg/cm^(3),182.25±28.00 to(88.55±25.68)mg/cm^(3)),lower than those in Northeast China((183.01±24.58)to(99.69±27.85)mg/cm^(3)),North China((188.93±24.80)to(95.89±26.12)mg/cm^(3)),East China((187.54±27.71)to(95.65±27.86)mg/cm^(3)).After 70 years of age,BMD tended to be the same in different regions(P>0.05).The BMD values in Central China and Southwest China were similar in the age group of 40-60 years(P>0.05).The BMD values in the health adult femles in the age group of 60 years in different regions of Chinawere all lower than those of bone mass abnormality(all P<0.05).The detection rate of osteoporosis in females over 50 years was the highest in Southwest China(25.65%)and it was the lowest in North China(17.30%).Conclusions This study establishes reference values of BMD under QCT in he

关 键 词：骨质疏松 健康成年女性 定量CT 骨密度 

分 类 号：R816.8[医药卫生—放射医学] R580[医药卫生—临床医学]