小檗碱脉冲控释PLGA微球的制备及其载体吸附作用研究  

Preparation of Berberine Pulse Controlled-release PLGA Microspheres and Its Adsorption on Carriers

作　　者：陈佩 鲁莹 卢光照 樊莉 Chen Pei;Lu Ying;Lu Guangzhao;Fan Li(Department of Pharmacy,Naval Medical University,Shanghai 200433,China)

机构地区：[1]中国人民解放军海军军医大学药学系,上海200433

出　　处：《广东化工》2022年第17期41-44,79,共5页Guangdong Chemical Industry

摘　　要：目的:研究小檗碱PLGA脉冲控释微球的制备工艺和体外释放特性。方法:建立小檗碱含量测定方法,采用复乳法制备小檗碱PLGA脉冲控释微球,透射电镜观察微球形态,定期取样考察小檗碱PLGA微球体外释放特性,并考察微球载体材料对小檗碱的吸附能力。结果:制备的小檗碱微球形态圆整光滑,载药量为0.35%,包封率为42.61%,无突释现象,初期释药量极少,22 d后开始逐渐大量释放。PLGA原料对小檗碱吸附作用明显,PLGA空白微球和PLGA有机溶剂对小檗碱吸附相对较弱。结论:成功制备了小檗碱PLGA微球,形态结构、包封率、释放特性均符合要求,初步考察结果表明PLGA原料对小檗碱吸附能力最强,可进行后续的研究。To study the preparation process and in vitro release characteristics of berberine PLGA pulse-controlled-release microspheres.Methods:A method for determination of berberine content was established.Berberine PLGA pulsed controlled-release microspheres were prepared by double emulsion method.The morphology of microspheres was observed by transmission electron microscope.Adsorption capacity of materials for berberine.Results:The prepared berberine microspheres were round and smooth,the drug loading was 0.35%,the encapsulation efficiency was 42.61%,and there was no sudden release phenomenon.PLGA raw material has obvious adsorption effect on berberine,while PLGA blank microspheres and PLGA organic solvent have relatively weak adsorption of berberine.Conclusion:Berberine PLGA microspheres were successfully prepared,and the morphological structure,encapsulation efficiency,and release characteristics all met the requirements.The preliminary investigation results showed that the PLGA raw material had the strongest adsorption capacity for berberine,and follow-up research could be carried out.

关 键 词：小檗碱 微球 脉冲控释 PLGA 吸附作用 

分 类 号：R94[医药卫生—药剂学]