米诺环素治疗慢性盆腔炎临床疗效观察  

Clinical Effect of Minocycline in the Treatment of Chronic Pelvic Inflammatory Disease

作　　者：卢园华[1] 沈德彬 张鹰庆[1] 李霖[1] LU Yuan-hua;SHEN De-bing;ZHANG Ying-qing;LI lin(Longyan City Second Hospital,Longyan 364000,China)

机构地区：[1]龙岩市第二医院,福建龙岩364000

出　　处：《海峡药学》2022年第9期126-128,共3页Strait Pharmaceutical Journal

摘　　要：目的探讨米诺环素治疗慢性盆腔炎临床效果。方法将我院2021年6~12月妇科门诊慢性盆腔炎患者114例,依据治疗方式不同分为:对照组(奥硝唑+妇科千金片)57例,观察组(米诺环素+妇科千金片)57例,口服治疗2周后,进行临床疗效、不良反应发生率和药物经济学成本-效果比较。结果对照组临床总有效率87.72%,观察组91.23%,P>0.05差异无统计学意义;不良反应发生率:对照组8.72%,观察组21.05%,差异显著,但未达到统计学意义(P=0.066);成本-效果比:对照组(1.16)优于观察组(2.02)。结论应用米诺环素治疗慢性盆腔炎,疗效确切与奥硝唑相比,总有效率无显著差异,且存在不良反应和用药成本较高问题,但对比分泌物病原体检测结果,发现其对支原体、衣原体患者转阴率高,是慢性盆腔炎复合多重病原体感染新的较好选择。OBJECTIVE To investigate the clinical effect of minocycline on chronic pelvic inflammatory disease.METHODS 114 patients with chronic pelvic inflammatory disease in gynecological outpatient department of our hospital from June to December 2021 were divided into control group and observation group,according to different treatment methods,with control group 57(ornidazole+gynecology qianjin tablet)and observation group 57(minocycline+gynecology qianjin tablet).After 2 weeks of oral treatment compare clinical efficacy、incidence of adverse reactions and pharmacoeconomic cost-effectiveness.RESULTS Control group total clinical response rate(87.72%)observation group91.23%(P>0.05),the difference was not statistically significant;incidence of adverse reactions:control group 8.72%,observation group 21.05%,the difference was significant,but not statistically significance(P=0.06);cost-effectiveness:the control group(1.16)was better than the observation group(2.02).CONCLUSION Minocycline was effective in treating chronic pelvic inflammatory disease,there was no significant difference in total effective rate compared with ornidazole,and there were adverse reactions and high drug cost.but compare the results of the secretions,found that it had a hight negative conversion rate for mycoplasma and chlamydia,it was a new and better choice for chronic pelvic inflammatory disease with complex multiple pathogen.

关 键 词：米诺环素 慢性盆腔炎 奥硝唑 妇科千金片 

分 类 号：R969.4[医药卫生—药理学]