卡瑞利珠单抗联合阿帕替尼致多器官功能衰竭1例  

A Case of Multiple Organ Failure Caused by Camrelizumab Combined with Apatinib

作　　者：蒋巧俐[1] 罗国庆[1] JIANG Qiao-li;LUO Guo-qing(Zhongnan Hospital of Wuhan University,Wuhan 430071,China)

机构地区：[1]武汉大学中南医院,湖北武汉430071

出　　处：《海峡药学》2022年第9期138-141,共4页Strait Pharmaceutical Journal

摘　　要：1例男性患者为治疗肝恶性肿瘤伴门静脉瘤栓。首次免疫+靶向治疗给予卡瑞利珠单抗200 mg静脉滴注,1 h后给予口服阿帕替尼靶向治疗,患者初始剂量为500 mg,口服,1日1次,用药后出现明显恶心呕吐,给予止吐药无明显好转,给药第三日将阿帕替尼减至250 mg,口服,1日1次。呕吐仍未见好转。第四日停药,患者仍有呕吐发生,同时引起心功能、肝功能、肾功能受损,凝血功能障碍,合并细菌感染,20 h后患者多器官功能衰竭导致死亡。A male patient was hospitalized for treating hepatic malignant tumor with portal venous tumor embolus.The patient was given camrelizumab 200 mg intravenously,followed by targeted treatment with oral apatinib 1 hour later.The initial dose was 500 mg daily,orally,once a day.An obvious nausea and vomiting was appeared after the administration,but no significant improvement was observed after the administration of antiemetic drugs.On the third day,after reducing the dose of apatinib to 250 mg daily,orally,once a day,the symptom of vomiting was still existed.On the fourth day,the vomiting didn′t recovery which was accompanied with a exacerbation of heart,liver and kidney impairments,coagulation dysfunction and bacterial infection.Finally,the patient died from multiple organ failure after 20 hours.

关 键 词：卡瑞利珠单抗 阿帕替尼 多器官功能衰竭 死亡 药品不良反应 

分 类 号：R969.3[医药卫生—药理学]