早产儿视网膜病变危险因素研究新进展  

Research progress on risk factors of retinopathy of prematurity

作　　者：王毅 吴斯琪[2] 肖亦爽[2] Wang Yi;Wu Si-qi;Xiao Yi-shuang(College of clinical medicine,Dali University,Dali 671000,China)

机构地区：[1]大理大学临床医学院,671000 [2]昆明市儿童医院眼科

出　　处：《中国斜视与小儿眼科杂志》2022年第3期47-48,I0016,5,38,共5页Chinese Journal of Strabismus & Pediatric Ophthalmology

基　　金：云南省应用基础研究计划项目(2013FZ248);昆明市卫计委昆明市儿童眼病诊治技术中心计划(2016-sw(技)-18)资助;昆明市卫计委十百千人才培养工程计划资助(2016-sw(后备)-34)。

摘　　要：早产儿视网膜病变(retinopathy of prematurity,ROP)是发生在早产儿眼部视网膜血管增生性疾病。ROP发病机制及危险因素复杂,除了出生孕周小及出生体质量低等公认的危险因素外,研究提出实验室指标包括血红蛋白、血小板、炎症及感染相关因子,以及最近研究较多的基因方面,包括血管内皮生长因子(VEGF)、内皮型一氧化氮合成酶(eNOS)、卷曲蛋白4、炎症相关基因多态性等因素均可能是其影响因素。本文就目前新提出的ROP危险因素和可能作用机制进行综述,以期早发现、早治疗,降低ROP的致盲率。Retinopathy of prematurity(ROP)is a kind of retinal vascular proliferative disease that occurs in premature infants.The pathogenesis and risk factors of ROP are complex.In addition to the recognized risk factors of small gestational age and low birth weight,many researchers have proposed laboratory indicators including hemoglobin,platelet,inflammation and infection related factors.And the gene aspect which has been studied more recently,including vascular endothelial growth factor(VEGF),endothelial nitric oxide synthase(eNOS),Curl protein 4,inflammation-associated gene polymorphisms and other factors may be the influencing factors of ROP.This article reviews the risk factors and possible mechanisms of ROP,in order to find and treat ROP early and reduce the blindness rate of ROP.

关 键 词：早产儿视网膜病变 实验室指标 基因多态性 危险因素 

分 类 号：R722.6[医药卫生—儿科] R774.1[医药卫生—临床医学]