机械化学法合成α-氟代苯乙酸酯的研究  

Synthesis ofα-Fluorophenylacetates by Mechanochemical Method

作　　者：李昆京 张舵 蒋世云[2] Li Kunjing;Zhang Duo;Jiang Shiyun(College of Biological and Chemical Engineering,Guangxi University of Science and Technology,Liuzhou 545000;Department of Medicine,Guangxi University of Science and Technology,Liuzhou 545000,China)

机构地区：[1]广西科技大学生物与化学工程学院,广西柳州545000 [2]广西科技大学医学部,广西柳州545000

出　　处：《广东化工》2022年第18期16-18,15,共4页Guangdong Chemical Industry

基　　金：桂科AD21220087。

摘　　要：氟苯乙酸酯类化合物作为重要的有机合成中间体,已经在农用化学品、医药工业、材料科学等领域得到了广泛的应用。传统的合成方法存在着反应条件苛刻,溶剂使用量大,难以回收等缺点,不符合可持续发展要求。近年来,无溶剂机械化学法作为绿色有机合成方法之一,极大地降低了环境污染,节约了生产成本和能耗,为反应的进一步工业化应用奠定了基础。本研究中我们发展了一种采用机械化学的无溶剂手段,通过可见光促进α-重氮酯反应高效的合成了一系列具有潜在生物活性的α-氟代苯乙酸酯。As important organic synthesis intermediates,α-fluoroaromatic esters have been widely used in agrochemicals,pharmaceutical industry,materials science and other fields.The traditional synthesis method has disadvantages such as harsh reaction conditions,large amount of solvent used,and difficulty in recycling,which does not meet the requirements of sustainable development.As one of the modern organic synthesis methods,the mechanochemical method avoids the use of solvents and improves the efficiency of the reaction.In this study,we developed a mechanochemical approach to efficiently synthesizeα-fluoroaromatic esters viaα-ester-based diazofluorination.Ten potentially biologically activeα-fluoroaryl ester compounds were synthesized using this method.

关 键 词：机械化学 氟化反应 重氮芳香酯 可见光 

分 类 号：TQ[化学工程]