萃取非甾体抗炎药物材料的制备及性能  

Preparation and properties of extracted materials for non-steroidal anti-inflammatory drugs

作　　者：李培英 赵嘉辉 刘博 赖华杰[1,2,3,4,5,6] LI Peiying;ZHAO Jiahui;LIU Bo;LAI Huajie(Guangzhou Institute of Chemistry,Chinese Academy of Sciences,Guangzhou 510650,Guangdong,China;University of Chinese Academy of Sciences,Beijing 100049,China;CAS Testing Technical Services(Guangzhou)Co.,Ltd.,Guangzhou 510650,Guangdong,China;CAS Engineering Laboratory for Special Fine Chemicals,Chinese Academy of Sciences,Guangzhou 510650,Guangdong,China;Guangdong Provincial Key Laboratory of Organic Polymer Materials for Electronics,Guangzhou 510650,Guangdong,China;New Materials Research Institute of CASCHEM(Chongqing)Co.,Ltd.,Chongqing 400714,China)

机构地区：[1]中国科学院广州化学研究所,广东广州510650 [2]中国科学院大学,北京100049 [3]中科检测技术服务(广州)股份有限公司,广东广州510650 [4]中国科学院新型特种精细化学品工程实验室,广东广州510650 [5]广东省电子有机聚合物材料重点实验室,广东广州510650 [6]中科广化(重庆)新材料研究院有限公司,重庆400714

出　　处：《精细化工》2022年第9期1781-1787,1819,共8页Fine Chemicals

基　　金：广东省省级科技计划项目——粤东中科检测技术服务中心(2017A040403030)。

摘　　要：通过Radziszewski反应制备了聚咪唑醋酸盐离子液体(PAIL),并涂覆在氧化纤维素层析纸(Oxi-CFP)上得到萃取纸(Oxi-CFP@PAIL)。采用ATR-IR、TGA、SEM和AFM对其进行了表征,并探讨了PAIL制备条件对Oxi-CFP@PAIL吸附托美汀、酮洛芬、萘普生和双氯芬酸4种非甾体抗炎药物(NSAIDs)的影响。结果表明,PAIL通过化学键成功地附着在Oxi-CFP表面上,同时Oxi-CFP@PAIL耐折度明显提高。60℃下制得的PAIL(质量分数为5%)水溶液对Oxi-CFP进行浸泡,Oxi-CFP@PAIL上PAIL的负载量最大,并且其对4种NSAIDs的单位面积吸附量最大。将萃取水溶液中含有羧基的NSAIDs的萃取纸用体积分数均为1%的甲酸和乙酸铵(1mol/L)水溶液的乙腈溶液进行解吸,并用三重四极杆液质联用仪(HPLC-MS/MS)检测,Oxi-CFP@PAIL对4种NSAIDs回收率均>80%。该方法检出限和定量限分别在0.02~0.10μg/L和0.07~0.33μg/L。Extraction paper(Oxi-CFP@PAIL) was fabricated by coating polyimidazolyl acetate ionic liquid(PAIL),synthesized via Radziszewski reaction,on oxidized cellulose chromatography paper(Oxi-CFP) and characterized by ATR-IR,TGA,SEM and AFM.Moreover,the influences of PAIL preparation conditions on the adsorption performance of Oxi-CFP@PAIL for 4 kinds of nonsteroidal anti-inflammatory drugs(NSAIDs)(tolmetin,ketoprofen,naproxen and diclofenac) were investigated.The results showed that PAIL was chemically bonded to the surface of Oxi-CFP successfully,and significantly improved the folding resistance of Oxi-CFP.Furthermore,the obtained Oxi-CFP@PAIL when the Oxi-CFP was immersed in the PAIL prepared at 60 ℃ aqueous solution with a mass fraction of 5% had the largest PAIL load and exhibited the best adsorption capacity per unit area for four NSAIDs.Desorption of 4 NSAIDS from Oxi-CFP@PAIL using acetonitrile solution containing 1%(volume fraction) formic acid and ammonium acetate(1 mol/L in water) followed by HPLC-MS/MS analyses indicated that recovery rate of Oxi-CFP@PAIL for 4 NSAIDs were higher than 80%.It was found out that the detection limit and quantitative limit of this analytical method were 0.02~0.10 μg/L and 0.07~0.33 μg/L,respectively.

关 键 词：薄膜萃取 萃取纸 聚离子液体 非甾体抗炎药物 功能材料 

分 类 号：TB34[一般工业技术—材料科学与工程]