激光人工皱缩在囊胚玻璃化冻融周期中的临床应用价值  

The Clinical Application Value of Laser Artificial Shrinkage in the Blastocyst Vitrification Freeze-thaw Cycle

作　　者：张小慧[1] 王世凯[1] 毛献宝[1] 李政达 韦娉嫔 薛林涛[1] Zhang Xiaohui;Wang Shikai;Mao Xianbao;Li Zhengda;Wei Pingpin;Xue Lintao(Reproductive Medical and Genetic Center,People’s Hospital of Guangxi Zhuang Autonomous Region,Nanning,530021)

机构地区：[1]广西壮族自治区人民医院生殖医学与遗传中心,南宁530021

出　　处：《基因组学与应用生物学》2022年第4期890-894,共5页Genomics and Applied Biology

基　　金：广西自然科学基金项目(2019GXNSFAA185056);广西卫健委课题项目(Z2015305)共同资助。

摘　　要：本研究探讨了激光人工皱缩在囊胚玻璃化冻融周期中的临床应用价值。通过回顾性分析2014年1月至2016年7月期间在广西壮族自治区人民医院生殖医学与遗传中心进行囊胚玻璃化冻融移植的449个周期,根据囊胚冷冻前是否进行激光人工皱缩分为激光人工皱缩组(n=193)和未皱缩组(n=256),比较两组的囊胚解冻复苏率、生化妊娠率、临床妊娠率、胚胎种植率、早期流产率、多胎妊娠率、活产率等临床结局指标。研究结果显示,激光人工皱缩组和未皱缩组的女方年龄、子宫内膜厚度、囊胚复苏率和平均移植胚胎数差异无统计学意义(P>0.05),激光人工皱缩组的生化妊娠率(63.21%)、临床妊娠率(56.99%)、活产率(50.78%)均高于未皱缩组的(49.41%,45.88%,39.23%)且差异有统计学意义(P<0.05)。本研究结果表明激光人工皱缩在囊胚玻璃化冻融周期中具有一定的临床应用价值,能够改善临床治疗结局。To investigate the clinical value of laser artificial shrinkage on the clinical outcome in vitrified-thawed blastocyst cycle,a total of 449 cycles of blastocyst vitrification were retrospectively analyzed in the reproductive medical and genetic center,People’s Hospital of Guangxi Zhuang Autonomous Region from January 2014 to July 2016.According to whether the blastocysts were artificially shrunk by laser before freezing,we divided them into laser artificial shrinkage group(193 cases)and non shrinkage group(256 cases).The survial rate of blastocysts,biochemical pregnancy rate,clinical pregnancy rate,embryo implantation rate,early abortion rate,multiple pregnancy rate,live birth rate and other clinical outcome indicators of the two groups were compared.The results showed that there were no significant difference in female age,endometrial thickness,survival rate of blastocysts and average number of transferred embryos between the laser artificial shrinkage group and non shrinkage group(P>0.05).The biochemical pregnancy rate(63.21%),clinical pregnancy rate(56.99%)and live birth rate(50.78%)in the laser artificial shrinkage group were higher than those in the non shrinkage group(49.41%,45.88%,39.23%),and the differences were statistically significant(P<0.05).The conclusion of this study shows that laser artificial shrinkage has a certain clinical application value in the vitrification cycle of blastocysts and can improve the clinical outcome.

关 键 词：囊胚 激光人工皱缩 玻璃化冷冻 解冻 临床结局 

分 类 号：R714.8[医药卫生—妇产科学]