覆膜金属罐中PBT/PET环状低聚物在食品中的迁移测试及基于膳食暴露量的风险评估  

Migration Test and Risk Assessment Based on Dietary Exposure of PBT/PET Cyclic Oligomers in Polymer-laminated Metal Cans

作　　者：李倩云 吴刚[2] 王亚 王晓龙 潘峰 张泓 邢航 李建文 朱蕾 LI Qian-yun;WU Gang;WANG Ya;WANG Xiao-long;PAN Feng;ZHANG Hong;XING Hang;LI Jian-wen;ZHU Lei(China National Center for Food Safety Risk Assessment,Beijing 100022,China;China National Research Institute of Food and Fermentation Industries,Beijing 100015,China)

机构地区：[1]国家食品安全风险评估中心,北京100022 [2]中国食品发酵工业研究院,北京100015

出　　处：《分析测试学报》2022年第10期1494-1500,共7页Journal of Instrumental Analysis

基　　金：科技部国家重点研发计划(2021YFF0601903)。

摘　　要：该文建立了一种超高效液相色谱-四极杆飞行时间质谱联用技术(UPLC-QTOF MS)测定覆膜金属罐包装食品中聚对苯二甲酸乙二醇酯(PET)和聚对苯二甲酸丁二醇酯(PBT)环状低聚物迁移量的方法。利用我国人群食物消费量、与食品接触面积和食品单位质量/体积比(S/V)的调查数据以及PET和PBT环状低聚物迁移试验数据,估算了我国人群对摄入的水果罐头、饮料和啤酒等以覆膜金属罐包装食品中PET和PBT环状低聚物的膳食暴露量,并按照毒理学关注阈值(TTC)决策树方法对其进行风险评估。结果显示,6种PET和PBT环状低聚物均属于Cramer Ⅲ类结构;其膳食暴露量最大值为1.234μg/kg·BW/d,低于Cramer Ⅲ类物质的阈值1.5μg/kg·BW/d。表明通过摄入覆膜金属罐包装的水果罐头、饮料和啤酒暴露于PBT和PET环状低聚物所引起的健康风险较低。The cyclic oligomers may migrate from polyethylene terephthalate(PET)and polybutylene terephthalate(PBT)coating of metal cans to foods,which may do harm to the human health.Hence,a method was developed for the detection of migration content of PBT/PET cyclic oligomers in coating of metal cans by ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UPLC-QTOF MS).According to the database of food consumption,the surface to volume(S/V)data of food contact materials and the migration tests of PET and PBT cyclic oligomers,the total intake of PET and PBT cyclic oligomers in chinese people exposing to coating of metal cans(fruit cans,drinks cans and beer cans)was estimated,and its risk was assessed by threshold of toxicological concern.Six kinds of PET and PBT cyclic oligomers belonged to the substances of Cramer Ⅲ.The maximum dietary exposure contents of PET and PBT cyclic oligomers were both 1.234μg/kg·BW/d,which were lower than 1.5μg/kg·BW/d,the threshold of substances of Cramer Ⅲ.As a result,the intake health risk of PET and PBT cyclic oligomers exposing on coating of metal cans(fruit cans,drinks cans and beer cans)was low,which required no undue attention.

关 键 词：聚对苯二甲酸乙二醇酯(PET) 聚对苯二甲酸丁二醇酯(PBT) 环状低聚物 覆膜金属罐 迁移测试 毒理学关注阈值(TTC) 风险评估 

分 类 号：O657.6[理学—分析化学] O657.7[理学—化学]