雏鸡用水凝胶药物载体的研制  

Preparation of Hydrogel Drug Carrier for Chicks

作　　者：孙媛媛 梁春彩 张海龙 刘聚祥[1] SUN Yuanyuan;LIANG Chuncai;ZHANG Hailong;LIU Juxiang(College of Veterinary Medicine,Hebei Agricultural University,Baoding 071000,China)

机构地区：[1]河北农业大学动物医学院,保定071000

出　　处：《中国畜牧兽医》2022年第10期4075-4084,共10页China Animal Husbandry & Veterinary Medicine

基　　金：河北省重点研发计划资助项目(18227517D);河北省现代农业产业技术体系蛋鸡产业创新团队项目(HBCT2018150210)。

摘　　要：【目的】通过物理交联法和表征分析,研制一种用于雏鸡的加水搅拌即用型水凝胶。【方法】制备水凝胶,通过预试验和Box-Behnken响应面法优化配方,使用扫描电子显微镜(SEM)观察微观结构,通过傅立叶红外光谱(FTIR)中化学基团吸收峰位置的偏移情况判断分子之间的相互作用,通过差示扫描量热仪(DSC)研究理化性质的变化。【结果】该水凝胶载体的最优配方为:4%聚丙烯酸钠高吸水树脂、10%麦芽糊精、1.5%瓜尔胶,余量为水。SEM结果显示,高吸水树脂和水凝胶均为多孔网状结构,加入麦芽糊精和瓜尔胶后结构更紧密,空洞更小。FTIR表明三者间存在氢键结合和分子间缠绕,无新化学基团生成。DSC结果显示三者发生相互作用,吸热峰峰形较宽,熔点上升,热稳定性提高。【结论】制备了一种雏鸡用水凝胶载体,该水凝胶制备方法简单、成本低廉、使用便捷。【Objective】 Through physical crosslinking method and characterization analysis, a kind of ready to use hydrogel with adding water and stirring was developed for chicks.【Method】 The hydrogel was prepared, and the formula was optimized by pre-experiment and Box-Behnken response surface method.Scanning electron microscope(SEM) was used to observe the micromorphology.Fourier transform infrared spectroscopy(FTIR) was used to judge the interaction between molecules according to the position shift of chemical group absorption peak, and the changes of physical and chemical properties were studied by differential scanning calorimetry(DSC).【Result】 The optimal formula of the hydrogel carrier was 4% sodium polyacrylate super absorbent resin, 10% maltodextrin, 1.5% guar gum, and water.SEM results showed that both super absorbent polymer and hydrogel had porous network structure, maltodextrin and guar gum had tighter structure and smaller cavity.FTIR showed that there were hydrogen bonding and intermolecular entanglement, and no new chemical groups were formed.DSC results showed that they were interacted with each other, their endothermic peaks were wider, their melting point was higher, and their thermal stability was improved.【Conclusion】 A hydrogel carrier for chicks was prepared with simple preparation method, low cost and convenient use.

关 键 词：雏鸡 水凝胶 响应面法 

分 类 号：S859[农业科学—临床兽医学]