贻贝粘蛋白敷料在宫颈LEEP术后创面修复及阴道微生态恢复中的应用  

Clinical Application of Mussel Adhesive Proteins Dressing in Wound Repair and Vaginal Microecological Recovery after Loop Electrosurgical Excision Procedure

作　　者：韦莹婷 杨宾烈[2] 黄莉霞[3] 顾李颖[1] 洪祖蓓[1] 王宇华[2] 邱丽华[1] WEI Ying-ting;YANG Bin-lie;HUANG Li-xia;GU Li-ying;HONG Zu-bei;WANG Yu-hua;QIU Li-hua(Department of Obstetrics and Gynecology,Shanghai Key Laboratory of Gynecologic Oncology,Ren Ji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China;Department of Obstetrics and Gynecology,Shanghai Pudong New Area People′s Hospital,Shanghai 201299,China;Shanghai Pudong Women and Children′s Health Care Hospital,Shanghai 201206,China)

机构地区：[1]上海交通大学医学院附属仁济医院妇产科,上海市妇科肿瘤重点实验室,200127 [2]上海市浦东新区人民医院妇产科 [3]上海市浦东新区妇幼保健院

出　　处：《国际妇产科学杂志》2022年第5期507-510,共4页Journal of International Obstetrics and Gynecology

基　　金：上海交通大学医学院附属仁济医院临床科研创新培育基金(RJPY-DZX-002)。

摘　　要：目的:评价贻贝粘蛋白(mussel adhesive proteins,MAP)敷料在宫颈环形电切术(loop electrosurgical excision procedure,LEEP)术后创面修复和阴道微生态恢复中的临床应用价值。方法:选取2020年11月—2021年4月因病理诊断宫颈鳞状上皮内病变行LEEP的患者,术后随机分为MAP组(30例)和不含MAP的安慰剂敷料对照组(30例),对比2组患者术后第3周创面愈合情况和术后第5周阴道微生态变化。结果:LEEP术后第3周,MAP组的创面愈合比例明显高于对照组(53.33%vs.13.33%,P=0.001);LEEP术后第5周,MAP组的阴道微生态较对照组明显好转(66.67%vs.3.33%,P=0.000)。结论:MAP敷料能够有效缩短宫颈LEEP术后创面愈合时间,改善阴道微生态。Objective:To evaluate the clinical application value of mussel adhesive proteins(MAP)dressing in wound repair and vaginal microecological recovery after loop electrosurgical excision procedure(LEEP).Methods:Patients who underwent LEEP for pathological diagnosis of cervical squamous intraepithelial diseases from November 2020 to April 2021 were randomly divided into 30 MAP group and 30 placebo control group without MAP.Wound healing was compared between the two groups at the 3rd week after surgery and vaginal microecological changes were compared between the two groups at the 5th week after surgery.Results:At the 3rd week after LEEP,the proportion of wound healing in the MAP group was significantly higher than that in the control group(53.33%vs.13.33%,P=0.001).At the 5th week after LEEP,the vaginal microecology of the MAP group was significantly improved compared with that of the control group(66.67%vs.3.33%,P=0.000).Conclusions:MAP dressing can effectively shorten the wound healing time after LEEP and improve vaginal microecology.

关 键 词：黏着剂 宫颈鳞状上皮内病变 生态型 伤口愈合 贻贝粘蛋白 环形电切术 

分 类 号：R713.4[医药卫生—妇产科学]