A new way to maintain CD8^(+) T-cell quiescence:interaction between CD8α and PILRα  

作　　者：Ke Jin Bowen Wu 

机构地区：[1]Laboratory of Human Diseases and Immunotherapies,West China Hospital,Sichuan University,610041 Chengdu,China [2]Institute of Immunology and Inflammation,Frontiers Science Center for Disease-related Molecular Network,West China Hospital,Sichuan University,610041 Chengdu,China [3]Department of Medicine,Mayo Clinic College of Medicine and Science,Rochester,MN 55905,USA

出　　处：《Signal Transduction and Targeted Therapy》2022年第8期2644-2645,共2页信号转导与靶向治疗（英文）

基　　金：supported by the Chinese National Natural Science Funds(81902947).

摘　　要：Recently,a paper published in Science by Zheng et al.reported that CD8αwas crucial to physiologically maintain the quiescent state of CD8^(+)T cells in peripheral lymphoid organs.Paired immunoglobulin-like type 2 receptor alpha(PILRα)was recognized as the ligand for CD8αand blockade of PILRα-CD8αinteraction would disrupt CD8^(+)T-cell quiescence.

关 键 词：CD8Α ORGANS al. 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]