Trends in insulin resistance:insights into mechanisms and therapeutic strategy  

作　　者：Mengwei Li Xiaowei Chi Ying Wang Sarra Setrerrahmane Wenwei Xie Hanmei Xu 

机构地区：[1]The Engineering Research Center of Synthetic Peptide Drug Discovery and Evaluation of Jiangsu Province,China Pharmaceutical University,Nanjing 210009,China [2]State Key Laboratory of Natural Medicines,Ministry of Education,China Pharmaceutical University,Nanjing 210009,China [3]Development Center for Medical Science&Technology National Health Commission of the People’s Republic of China,100044 Beijing,China [4]NANJING ANJI BIOTECHNOLOGY CO.LTD,Nanjing 210033,China

出　　处：《Signal Transduction and Targeted Therapy》2022年第8期2762-2786,共25页信号转导与靶向治疗（英文）

基　　金：supported by NANJING ANJI BIOTECHNOLOGY Co.Ltd,the Project Program of State Key Laboratory of Natural Medicines(SKLNMZZ202028);National Natural Science Foundation of China(82103118)。

摘　　要：The centenary of insulin discovery represents an important opportunity to transform diabetes from a fatal diagnosis into a medically manageable chronic condition.Insulin is a key peptide hormone and mediates the systemic glucose metabolism in different tissues.Insulin resistance(IR)is a disordered biological response for insulin stimulation through the disruption of different molecular pathways in target tissues.Acquired conditions and genetic factors have been implicated in IR.Recent genetic and biochemical studies suggest that the dysregulated metabolic mediators released by adipose tissue including adipokines,cytokines,chemokines,excess lipids and toxic lipid metabolites promote IR in other tissues.IR is associated with several groups of abnormal syndromes that include obesity,diabetes,metabolic dysfunction-associated fatty liver disease(MAFLD),cardiovascular disease,polycystic ovary syndrome(PCOS),and other abnormalities.Although no medication is specifically approved to treat IR,we summarized the lifestyle changes and pharmacological medications that have been used as efficient intervention to improve insulin sensitivity.Ultimately,the systematic discussion of complex mechanism will help to identify potential new targets and treat the closely associated metabolic syndrome of IR.

关 键 词：METABOLISM STIMULATION diagnosis 

分 类 号：R58[医药卫生—内分泌]