Uncover landfilled antimicrobial resistance:a critical review of antibiotics flux,resistome dynamics and risk assessment  

作　　者：Dong Wu Yinglong Su Panliang Wang Jue Zhao Jiawen Xie Bing Xie 

机构地区：[1]Shanghai Engineering Research Center of Biotransformation of Organic Solid Waste,School of Ecological and Environmental Sciences,Shanghai Key Lab for Urban Ecological Processes and Eco-Restoration,East China Normal University,Shanghai 200241,China [2]Shanghai Institute of Pollution Control and Ecological Security,Shanghai 200092,China [3]Key Laboratory of Environmental Pollution Monitoring and Disease Control,Ministry of Education,Guizhou Medical University,Guizhou 550001,China [4]Department of Civil and Environmental Engineering and Research Institute for Sustainable Urban Development,The Hong Kong Polytechnic University,Hong Kong 999077,China

出　　处：《National Science Open》2022年第2期12-33,共22页国家科学进展（英文）

基　　金：supported by the National Key Research and Development Program of China(2018YFC1901000);National Natural Science Foundation of China(42107457 and 21577038);Hong Kong Scholar Scheme(XJ2018030);the Fundamental Research Funds for the Central Universities,Shanghai City Sci-Tech Joint Research Project in Yangtze River Delta of Shanghai Municipal Science and Technology Commission(20232420700);Shanghai Engineering Research Center of Biotransformation of Organic Solid Waste(19DZ2254400).

摘　　要：Municipal solid waste(MSW)landfill is one of the most important reservoirs of antimicrobial resistance(AMR)in urban environments.By reviewing~120 published cases worldwide,we found that leachate-borne antibiotics were at theμg/L level,and meanwhile,around 8 tons of antibiotics(including the clinically relevant ones)annually leached from the MSW landfills in China.During a decade-long landfilling process,the leachate-borne bacteria mainly originating from humanassociated waste(>40%)formed a community network being versatile to the drastic environmental changes.Among them,the keystone species(Proteobacteria subtaxa)functioned for metabolizing the most available substrate in leachates and were also the hosts of mobile antibiotic resistance genes(ARGs),which suggested the enduring and close associations between bacterial community and resistome.These leachate-borne ARGs were highly mobile via plasmid-mediated horizontal gene transfer,especially in less aged leachates(<10 yr).MetaCompare showed that the AMR-hazard index of landfill-specific airborne particles(index=20.5)was significantly higher than that of drinking water(index=17.81,P<0.01).Human daily exposure of ARGs amounted to an inhalation of(5.83±0.16)×105 copies of ARGs,being tenfold higher than that ingestion of drinking water,which implies landfills as a non-ignorable AMR source.

关 键 词：landfill leachates antibiotic resistance antibiotics flux health risks 

分 类 号：X705[环境科学与工程—环境工程]