血清ACA、AOPP以及抗-β2-GPⅠ水平与妊娠期糖尿病孕妇不良妊娠结局的关系  

The relationship between serum ACA,AOPP,anti-β2-GPⅠantibody and adverse pregnancy outcomes in pregnant women with gestational diabetes mellitus

作　　者：李阿利 关静 LI Ali;GUAN Jing(Department of Obstetrics and Gynecology,the 987th Hospital of the PLA Joint Logistics Support Force,Baoji,Shaanxi 721000,China;Department of Obstetrics,Baoji High-tech Hospital,Baoji,Shaanxi 721000,China)

机构地区：[1]中国人民解放军联勤保障部队第九八七医院妇产科,陕西宝鸡721000 [2]宝鸡高新医院产科,陕西宝鸡721000

出　　处：《检验医学与临床》2022年第20期2829-2832,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨血清抗心磷脂抗体(ACA)、晚期氧化蛋白产物(AOPP)以及抗β2-GPⅠ抗体(抗-β2-GPⅠ)水平与妊娠期糖尿病孕妇不良妊娠结局的关系。方法选择在2019年8月至2021年5月解放军联勤保障部队第九八七医院诊治的妊娠期糖尿病孕妇78例作为妊娠期糖尿病组,同期选择在该院进行健康体检的非妊娠期糖尿病孕妇78例作为对照组。检测两组血清ACA、AOPP以及抗-β2-GPⅠ水平,调查、随访孕妇的妊娠结局并进行相关性分析。结果妊娠期糖尿病组的空腹血糖、餐后2 h血糖、收缩压、吸烟率都高于对照组(P<0.05),两组舒张压、饮酒率对比差异无统计学意义(P>0.05)。妊娠期糖尿病组的ACA、AOPP以及抗-β2-GPⅠ水平均高于对照组(P<0.05)。妊娠期糖尿病组的不良妊娠结局率为19.2%,高于对照组的1.4%(P<0.05)。不良妊娠结局孕妇的产次、孕次、孕周、年龄、身高等与良好妊娠结局孕妇的一般资料比较差异无统计学意义(P>0.05),ACA、AOPP以及抗-β2-GPⅠ水平对比差异有统计学意义(P<0.05)。非条件Logistic回归分析显示血清ACA、AOPP、抗-β2-GPⅠ水平为导致不良妊娠结局发生的重要因素(P<0.05)。结论妊娠期糖尿病孕妇多伴随有血清ACA、AOPP以及抗-β2-GPⅠ水平的高表达,三者也为导致妊娠期糖尿病孕妇发生不良妊娠结局的重要因素。Objective To investigate the relationship between serum anticardiolipin antibody(ACA),advanced oxidized protein products(AOPP),anti-β2-GPⅠantibody and the adverse pregnancy outcomes of pregnant women with gestational diabetes mellitus.Methods from August 2019 to May 2021,78 cases of pregnant women with gestational diabetes diagnosed and treated in 987 hospital of PLA Joint Logistic Support force were selected as gestational diabetes group.And the other 78 cases of pregnant women with non gestational diabetes mellitus in our hospital were selected as control group.The serum ACA,AOPP and anti-β2-GPⅠantibody level were detected,investigated and followed up the pregnancy outcome of pregnant women,and analyzed the correlation.Results The fasting blood glucose,postprandial 2 h blood glucose,systolic blood pressure and smoking rate in the gestational diabetes group were higher than those in the control group(P<0.05).There were no difference in the diastolic blood pressure and drinking rate compared between the two groups(P>0.05).The serum ACA,AOPP,anti-β2-GPⅠantibody levels in gestational diabetes group were higher than that in the control group(P<0.05).The incidences of adverse pregnancy outcomes in gestational diabetes group were 19.2%that were higher than that in control group(1.4%,P<0.05).There was no significant difference in the number of births,gestation,gestational age,age and height of pregnant women with adverse pregnancy outcomes compared with the general data of good pregnancy outcomes(P>0.05),ACA,AOPP and anti-β2-GPⅠantibody levels were significantly different(P<0.05).Unconditional Logistic regression analysis showed that serum ACA,AOPP,anti-β2-GPⅠantibody were important factors leaded to adverse pregnancy outcome(P<0.05).Conclusion Pregnant women with gestational diabetes mellitus are mostly accompanied by serum ACA,AOPP,anti-β2-GPⅠantibody,which are also the important factors in the occurrence of adverse pregnancy outcomes in pregnant women with gestational diabetes mellitus.

关 键 词：妊娠期糖尿病 抗心磷脂抗体 晚期氧化蛋白产物 抗β2-GPⅠ抗体 妊娠结局 

分 类 号：R446.11[医药卫生—诊断学]