Co-existence and co-infection of influenza A viruses and coronaviruses: Public health challenges  

作　　者：Jing Yang Yuhuan Gong Chunge Zhang Ju Sun Gary Wong Weifeng Shi Wenjun Liu George FGao Yuhai Bi 

机构地区：[1]CAS Key Laboratory of Pathogenic Microbiology and Immunology,Institute of Microbiology,Center for Influenza Research and Early-warning(CASCIRE),CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID),Chinese Academy of Sciences,Beijing 100101,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]Institut Pasteur of Shanghai,Chinese Academy of Sciences,Shanghai 200031,China [4]Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong,Shandong First Medical University&Shandong Academy of Medical Sciences,Taian 271016,China

出　　处：《The Innovation》2022年第5期38-47,共10页创新（英文）

基　　金：supported by the National Key R&D Program of China(2021YFC2300903,2021YFE0109100,and 2021YFC2301300);Strategic Priority Research Program of Chinese Academy of Sciences(CAS)(XDB29010102);National Natural Science Foundation of China(NSFC)(32161123001,82161148010,and 32041010);Beijing Natural Science Foundation(M22029 and L192007);CAS Southeast Asia Biodiversity Research Institute(151C53KYSB20210023);Shenzhen Science and Technology Research and Development Project(JCYJ20180504165549581);the National Science and Technology Infrastructure of China(National Pathogen Resource Center-NPRC-32);supported by the Special Program of China Postdoctoral Science Foundation(2020T130123ZX);supported by National Natural Science Foundation of China(NSFC)Outstanding Young Scholars(31822055);Youth Innovation Promotion Association of CAS(Y2021034);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202208)。

摘　　要：Since the 20th century,humans have lived through five pandemics caused by influenza A viruses(IAVs)(H1N1/1918,H2N2/1957,H3N2/1968,and H1N1/2009)and the coronavirus(CoV)severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).IAVs and CoVs both have broad host ranges and share multiple hosts.Virus co-circulation and even co-infections facilitate genetic reassortment among IAVs and recombination among CoVs,further altering virus evolution dynamics and generating novel variants with increased cross-species transmission risk.Moreover,SARS-CoV-2 may maintain longterm circulation in humans as seasonal IAVs.Co-existence and co-infection of both viruses in humans could alter disease transmission patterns and aggravate disease burden.Herein,we demonstrate how virus-host ecology correlates with the co-existence and co-infection of IAVs and/or CoVs,further affecting virus evolution and disease dynamics and burden,calling for active virus surveillance and countermeasures for future public health challenges.

关 键 词：INFECTION MAINTAIN GENERATING 

分 类 号：R511.7[医药卫生—内科学] R373[医药卫生—临床医学]