Temperature acclimation in hot-spring snakes and the convergence of cold response  

作　　者：Chaochao Yan Wei Wu Wenqi Dong Bicheng Zhu Jiang Chang Yunyun Lv Shilong Yang Jia-Tang Li 

机构地区：[1]CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration and Biodiversity Conservation Key Laboratory of Sichuan Province,Chengdu Institute of Biology,Chinese Academy of Sciences,Chengdu 610041,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]College of Wildlife and Protected Area,Northeast Forestry University,Harbin 660223,China [4]State Key Laboratory of Environmental Criteria and Risk Assessment,Chinese Research Academy of Environmental Sciences,Beijing 100085,China [5]College of Life Science,Neijiang Normal University,Neijiang,Sichuan 641100,China [6]Center for Excellence in Animal Evolution and Genetics,Chinese Academy of Sciences,Kunming 650223,China

出　　处：《The Innovation》2022年第5期97-106,共10页创新（英文）

基　　金：supported by the Strategic Priority Research Program of Chinese Academy of Sciences(CAS)(XDB31000000);the National Natural Science Foundation of China(32100396);the Second Tibetan Plateau Scientific Expedition and Research Program(STEP)(2019QZKK0501);Biodiversity Survey,Monitoring and Assessment Project of Ministry of Ecology and Environment,The People’s Republic of China,China(2019HB2096001006);Key Research Program of Frontier Sciences,CAS(QYZDB-SSW-SMC058);the International Partnership Program of Chinese Academy of Sciences(151751KYSB20190024);the Sichuan Science and Technology Program(2021JDJQ0002;2021YJ0088).

摘　　要：Animals have evolved sophisticated temperature-sensing systems and mechanisms to detect and respond to ambient temperature changes.As a relict species endemic to the Qinghai-Tibet Plateau,hot-spring snake(Thermophis baileyi)survived the dramatic changes in climate that occurred during plateau uplift and ice ages,providing an excellent opportunity to explore the evolution of temperature sensation in ectotherms.Based on distributional information and behavioral experiments,we found that T.baileyi prefer hotspring habitats and respond more quickly to warmth than other two snakes,suggesting that T.baileyi may evolve an efficient thermal-sensing system.Using high-quality chromosome-level assembly and comparative genomic analysis,we identified cold acclimation genes experiencing convergent acceleration in high-altitude lineages.We also discovered significant evolutionary changes in thermosensation-and thermoregulation-related genes,including the transient receptor potential(TRP)channels.Among these genes,TRPA1 exhibited three species-specific amino acid replacements,which differed from those found in infrared imaging snakes,implying different temperature-sensing molecular strategies.

关 键 词：HABITAT SPRING SNAKE 

分 类 号：Q95[生物学—动物学]