The emerging roles of retromer and sorting nexins in the life cycle of viruses  

作　　者：Yue Lu Ping He Yuxuan Zhang Yongwen Ren Leiliang Zhang 

机构地区：[1]Department of Clinical Laboratory Medicine,The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan Hospital,Jinan,250013,China [2]Department of Pathogen Biology,School of Basic Medical Sciences,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan,250117,China [3]Medical Science and Technology Innovation Center,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan,250117,China

出　　处：《Virologica Sinica》2022年第3期321-330,共10页中国病毒学（英文版）

基　　金：supported by grants from National Natural Science Foundation of China(81871663 and 82072270);Undergraduate Science and Technology Innovation Plan of International Class of Clinical Medicine in Shandong First Medical University(ZYKC2019-016);Academic promotion programme of Shandong First Medical University(2019LJ001)。

摘　　要：Retromer and sorting nexins(SNXs)transport cargoes from endosomes to the trans-Golgi network or plasma membrane.Recent studies have unveiled the emerging roles for retromer and SNXs in the life cycle of viruses,including members of Coronaviridae,Flaviviridae and Retroviridae.Key components of retromer/SNXs,such as Vps35,Vps26,SNX5 and SNX27,can affect multiple steps of the viral life cycle,including facilitating the entry of viruses into cells,participating in viral replication,and promoting the assembly of virions.Here we present a comprehensive updated review on the interplay between retromer/SNXs and virus,which will shed mechanistic insights into controlling virus infection.

关 键 词：RETROMER CORONAVIRIDAE FLAVIVIRIDAE RETROVIRIDAE Sorting nexin(SNX) 

分 类 号：R373[医药卫生—病原生物学]