Nogo蛋白与心肌纤维化关系的研究进展  

Research progress on the relationship between Nogo protein and myocardial fibrosis

作　　者：胡耀文 孙艳荣 孙昊哲 王文娟 张苏欣 秦丽华 HU Yao-wen;SUN Yan-rong;SUN Hao-zhe;WANG Wen-juan;ZHANG Su-xin;QIN Li-hua(Department of Anatomy and Histoembryology,School of Basic Medical Sciences,Peking University Health Science Center,Beijing100083,China)

机构地区：[1]北京大学医学部基础医学院解剖学与组织学胚胎学系,北京100083

出　　处：《解剖学报》2022年第5期674-679,共6页Acta Anatomica Sinica

基　　金：国家自然科学基金(81873818)。

摘　　要：Nogo蛋白是网状蛋白家族的第4个成员,编码基因转录产生的Nogo mRNA由于启动子和剪切方式不同形成3种不同的RNA转录体,分别为Nogo-A、Nogo-B和Nogo-C蛋白。Nogo蛋白最初在中枢神经系统中被发现,后证明广泛表达于心、肝和血管内皮等外周组织。研究表明,Nogo蛋白可通过RhoA/Rho相关激酶(ROCK)通路、内质网应激、Sce61α等多种信号通路参与心肌纤维化的调控过程。我们就Nogo-A、Nogo-B、Nogo-C与心肌纤维化的关系作简要介绍。Nogo protein is the fourth member of reticulin family.Nogo mRNA produced by encoding gene transcription,forms three different RNA transcripts due to different promoter and splicing modes,namely Nogo-A,Nogo-B and Nogo-C protein.Nogo protein was first found in the central nervous system,and then proved to be widely expressed in peripheral tissues such as heart,liver and vascular endothelium.Studies have shown that Nogo protein can participate in the regulation of myocardial fibrosis through RhoA/Rho-associated kinase(ROCK)pathway,endoplasmic reticulum stress,Sce61αand other signaling pathways.In this paper,the relationship between Nogo-A,Nogo-B,Nogo-C and myocardial fibrosis is briefly introduced.

关 键 词：NOGO-A Nogo-B Nogo-C 心肌纤维化 

分 类 号：R331.31[医药卫生—人体生理学]