Metabonomics fingerprint of volatile organic compounds in serum and urine of pregnant women with gestational diabetes mellitus  

作　　者：Si-Ri-Gu-Leng Sana Guang-Min Chen Yang Lv Lei Guo En-You Li 

机构地区：[1]Department of Anesthesiology,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang Province,China

出　　处：《World Journal of Diabetes》2022年第10期888-899,共12页世界糖尿病杂志（英文版）（电子版）

摘　　要：BACKGROUND Gestational diabetes mellitus(GDM)is a metabolic disease with an increasing annual incidence rate.Our previous observational study found that pregnant women with GDM had mild cognitive decline.AIM To analyze the changes in metabonomics in pregnant women with GDM and explore the mechanism of cognitive function decline.METHODS Thirty GDM patients and 30 healthy pregnant women were analyzed.Solid-phase microextraction gas chromatography/mass spectrometry was used to detect organic matter in plasma and urine samples.Statistical analyses were conducted using principal component analysis and partial least squares discriminant analysis.RESULTS Differential volatile metabolites in the serum of pregnant women with GDM included hexanal,2-octen-1-ol,and 2-propanol.Differential volatile metabolites in the urine of these women included benzene,cyclohexanone,1-hexanol,and phenol.Among the differential metabolites,the conversion of 2-propanol to acetone may further produce methylglyoxal.Therefore,2-propanol may be a potential marker for serum methylglyoxal.CONCLUSION 2-propanol may be a potential volatile marker to evaluate cognitive impairment in pregnant women with GDM.

关 键 词：Gestational diabetes mellitus Gas chromatography/mass spectrometry Humoral biomarkers 2-propanol 

分 类 号：R714.256[医药卫生—妇产科学]