Oxidative stress bridges the gut microbiota and the occurrence of frailty syndrome  

作　　者：Si-Yue Chen Tong-Yao Wang Chao Zhao Hui-Jing Wang 

机构地区：[1]Laboratory of Neuropsychopharmacology,College of Fundamental Medicine,Shanghai University of Medicine&Health Science,Shanghai 201318,China [2]Key Laboratory of Medical Molecular Virology,School of Basic Medical Sciences,Shanghai Medical College&National Clinical Research Center for Aging and Medicine,Huashan Hospital,Shanghai Medical College,Fudan University,Shanghai 200032,China [3]Shanghai Frontiers Science Center of Pathogenic Microbes and Infection,Shanghai Frontiers Science Center,Shanghai 200032,China

出　　处：《World Journal of Gastroenterology》2022年第38期5547-5556,共10页世界胃肠病学杂志（英文版）

基　　金：the National Key Research and Development Program of China,No.2018YFC2002000 and 2018YFC2000500/03;Shanghai Natural Science Foundation,No.21ZR1409200

摘　　要：The incidence of frailty gradually increases with age.This condition places a heavy burden on modern society,of which the aging population is increasing.Frailty is one of the most complicated clinical syndromes;thus,it is difficult to uncover its underlying mechanisms.Oxidative stress(OS)is involved in frailty in multiple ways.The association between the gut microbiota(GM)and frailty was recently reported.Herein,we propose that OS is involved in the association between the GM and the occurrence of frailty syndrome.An imbalance between oxidation and antioxidants can eventually lead to frailty,and the GM probably participates in this process through the production of reactive oxygen species.On the other hand,OS can disturb the GM.Such dysbiosis consequently induces or exacerbates tissue damage,leading to the occurrence of frailty syndrome.Finally,we discuss the possibility of improving frailty by intervening in the vicious cycle between the imbalance of OS and dysbiosis.

关 键 词：Oxidative stress Gut microbiota Frail syndrome Traditional Chinese medicine 

分 类 号：R592[医药卫生—老年医学]