机构地区：[1]Department of Environmental Health,Croatian Institute of Public Health,Zagreb 10000,Croatia [2]Department of Radiology,Merkur University Hospital,Zagreb 10000,Croatia [3]Department of Gastroenterology and Hepatology,University Hospital Center Zagreb,Zagreb 10000,Croatia [4]School of Medicine,University of Zagreb,Zagreb 10000,Croatia [5]Department of Virology,Croatian Veterinary Institute,Zagreb 10000,Croatia [6]Department of Social Medicine and Epidemiology,Faculty of Medicine University of Rijeka,Rijeka 51000,Croatia [7]Department of Occupational and Environmental Health,Andrija Stampar School of Public Health,Zagreb 10000,Croatia [8]Department of Virology,Croatian Institute of Public Health,Zagreb 10000,Croatia [9]Department of Microbiology and Infectious Diseases with Clinic,Faculty of Veterinary Medicine University of Zagreb,Zagreb 10000,Croatia [10]Department of Gerontology and Social Medicine,Andrija Stampar Teaching Institute of Public Health,Zagreb 10000,Croatia [11]Institute of Emergency Medicine of Krapina-Zagorje County,Krapina 49000,Croatia [12]Department of Nephrology,Merkur University Hospital,Zagreb 10000,Croatia [13]Department of Anesthesiology,University Hospital Merkur,Zagreb 10000,Croatia [14]Department for Social Psychiatry,Psychotherapy and Psychodiagnostics,University Clinical Hospital Center“Sestre Milosrdnice”,Zagreb 10000,Croatia
出 处：《World Journal of Gastroenterology》2022年第37期5494-5505,共12页世界胃肠病学杂志（英文版）
基 金：the Croatian Science Foundation(Emerging and Neglected Hepatotropic Viruses after Solid Organ and Hematopoietic Stem Cell Transplantation to Mrzljak A),No.IP-2020-02-7407.
摘 要：BACKGROUND Hepatitis E virus(HEV)is an emerging virus of global health concern.The seroprevalence rates differ greatly according to geographic region and population group.AIM To analyze the seroprevalence of HEV in exposed(animal-related professions)and nonexposed populations,as well as solid organ and hematopoietic stem cell transplant patients.METHODS Forestry workers(n=93),hunters(n=74),and veterinarians(n=151)represented the exposed population.The general population(n=126)and pregnant women(n=118)constituted the control group.Transplant patients included liver transplant recipients(LTRs)(n=83),kidney transplant recipients(KTRs)(n=43),and hematopoietic stem cell transplant recipients(HSCRs)(n=39).HEV immunoglobulin G antibodies were detected using the enzyme-linked immunosorbent assay and confirmed by the immunoblot test.RESULTS The HEV seroprevalence significantly differed between groups:Veterinarians 15.2%,hunters 14.9%,forestry workers 6.5%,general population 7.1%,and pregnant women 1.7%.In transplant patients,the seropositivity was highest in LTRs(19.3%),while in KTRs and HSCRs,the seroprevalence was similar to the general population(6.9%and 5.1%,respectively).A significant increase in seropositivity with age was observed from 2.9%in individuals less than 30 years to 23.5%in those older than 60 years.Sociodemographic characteristics(sex,educational level,area of residence,and number of household members),eating habits(game meat,offal,and pork products consumption),and environmental and housing conditions(drinking water supply,type of water drainage/sewer,waste disposal,domestic animals)were not associated with HEV seropositivity.However,individuals who reported a pet ownership were more often seropositive compared to those who did not have pet animals(12.5%vs 7.0%).CONCLUSION The results of this study showed that individuals in professional contact with animals and LTRs are at higher risk for HEV infection.In addition,age is a significant risk factor for HEV seropositivity.
关 键 词：Hepatitis E virus SEROPREVALENCE VETERINARIANS HUNTERS Forestry workers Transplant patients Croatia
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