Effects of COVID-19 on the liver:The experience of a single center  

作　　者：Valentina Liakina Ieva Stundiene Gabriele Milaknyte Ramune Bytautiene Rosita Reivytyte Roma Puronaite Gintare Urbanoviciute Edita Kazenaite 

机构地区：[1]Centre of Hepatology,Gastroenterology and Dietetics,Clinic of Gastroenterology,Nephrourology and Surgery,Institute of Clinical Medicine,Faculty of Medicine,Vilnius University,Vilnius 01513,Lithuania [2]Department of Chemistry and Bioengineering,Faculty of Fundamental Sciences,VILNIUS TECH,Vilnius 10223,Lithuania [3]Faculty of Medicine,Vilnius University,Vilnius 01513,Lithuania [4]Clinic of Cardiac and Vascular Diseases,Institute of Clinical Medicine,Faculty of Medicine,Vilnius University,Vilnius 01513,Lithuania [5]Institute of Data Science and Digital Technologies,Faculty of Mathematics and Informatics,Vilnius University,Vilnius 01513,Lithuania [6]Department of Pathology,Forensic Medicine and Pharmacology,Institute of Biomedical Sciences,Faculty of Medicine,Vilnius University,Vilnius 01513,Lithuania

出　　处：《World Journal of Gastroenterology》2022年第39期5735-5749,共15页世界胃肠病学杂志（英文版）

摘　　要：BACKGROUND The coronavirus disease 2019(COVID-19)was perhaps the most severe global health crisis in living memory.Alongside respiratory symptoms,elevated liver enzymes,abnormal liver function,and even acute liver failure were reported in patients suffering from severe acute respiratory disease coronavirus 2 pneumonia.However,the precise triggers of these forms of liver damage and how they affect the course and outcomes of COVID-19 itself remain unclear.AIM To analyze the impact of liver enzyme abnormalities on the severity and outcomes of COVID-19 in hospitalized patients.METHODS In this study,684 depersonalized medical records from patients hospitalized with COVID-19 during the 2020-2021 period were analyzed.COVID-19 was diagnosed according to the guidelines of the National Institutes of Health(2021).Patients were assigned to two groups:those with elevated liver enzymes(Group 1:603 patients),where at least one out of four liver enzymes were elevated(following the norm of hospital laboratory tests:alanine aminotransferase(ALT)≥40,aspartate aminotransferase(AST)≥40,gamma-glutamyl transferase≥36,or alkaline phosphatase≥150)at any point of hospitalization,from admission to discharge;and the control group(Group 2:81 patients),with normal liver enzymes during hospitalization.COVID-19 severity was assessed according to the interim World Health Organization guidance(2022).Data on viral pneumonia complications,laboratory tests,and underlying diseases were also collected and analyzed.RESULTS In total,603(88.2%)patients produced abnormal liver test results.ALT and AST levels were elevated by a factor of less than 3 in 54.9%and 74.8%of cases with increased enzyme levels,respectively.Patients in Group 1 had almost double the chance of bacterial viral pneumonia complications[odds ratio(OR)=1.73,P=0.0217],required oxygen supply more often,and displayed higher biochemical inflammation indices than those in Group 2.No differences in other COVID-19 complications or underlying diseases were observed between groups.Preexis

关 键 词：COVID-19 SARS-CoV-2 Liver enzymes COMPLICATIONS Underlying disease Disease severity 

分 类 号：R563.1[医药卫生—呼吸系统] R575[医药卫生—内科学]