Link between COVID-19 vaccines and myocardial infarction  

作　　者：Umema Zafar Hamna Zafar Mian Saad Ahmed Madiha Khattak 

机构地区：[1]Department of Physiology,Khyber Medical College,Peshawar 25000,Pakistan [2]Department of Medicine,Khyber Teaching Hospital,Peshawar 25000,Pakistan [3]Department of Forensic Medicine,Khyber Medical College,Peshawar 25000,Pakistan

出　　处：《World Journal of Clinical Cases》2022年第28期10109-10119,共11页世界临床病例杂志

摘　　要：BACKGROUND Vaccines for coronavirus disease 2019(COVID-19) include Ch Ad Ox1-SARS-COV-2(Astra Zeneca),Ad26.COV2.S(Janssen),m RNA-1273(Moderna),BNT162b2(Pfizer),BBIBP-Cor V(Sinopharm),Corona Vac(Sinovac),and Bharat Biotech BBV152(Covaxin).AIM To find the association between COVID-19 vaccines and myocardial infarction(MI).METHODS This is a systematic review that involved searching databases such as MEDLINE,EMBASE,and Pak Medi Net after making a search strategy using Me SH and Emtree terms.Eligibility criteria were set,and studies having no mention of MI as a complication of COVID-19 vaccination,protocols,genetic studies,and animal studies were excluded.Data was extracted using a predesigned extraction table,and 29 studies were selected after screening and applying the eligibility criteria.RESULTS The majority of studies mentioned Astra Zeneca(18 studies) followed by Pfizer(14 studies) and Moderna(9 studies) in subjects reporting MI after vaccination.Out of all the studies,69% reported MI cases after the first COVID-19 vaccination dose and 14% after the second,44% reported ST-segment elevation MI,and 26% reported non-ST-segment elevation MI.The mortality rate was 29% after MI.CONCLUSION In conclusion,many studies linked MI to COVID-19 vaccinations,but no definitive association could be found.

关 键 词：SARS-Co V-2 infection VACCINATION Myocardial infarction ASSOCIATION PFIZER Astra Zeneca Moderna Sinovac Janssen Covaxin 

分 类 号：R542.22[医药卫生—心血管疾病] R186[医药卫生—内科学]