COVID-19-associated disseminated mucormycosis:An autopsy case report  

作　　者：Daisuke Kyuno Terufumi Kubo Mitsuhiro Tsujiwaki Shintaro Sugita Michiko Hosaka Hazuki Ito Keisuke Harada Akira Takasawa Yusaku Kubota Kumi Takasawa Yusuke Ono Kazufumi Magara Eichi Narimatsu Tadashi Hasegawa Makoto Osanai 

机构地区：[1]Department of Pathology,Sapporo Medical University,Sapporo 0608556,Hokkaido,Japan [2]Department of Surgical Pathology,Sapporo Medical University,Sapporo 0608556,Japan [3]Department of Emergency Medicine,Sapporo Medical University,Sapporo 0608556,Japan

出　　处：《World Journal of Clinical Cases》2022年第28期10358-10365,共8页世界临床病例杂志

摘　　要：BACKGROUND Reports of mucormycosis,an infectious disease that commonly affects immunocompromised individuals,have increased during the ongoing coronavirus disease 2019(COVID-19) pandemic.Disseminated mucormycosis associated with COVID-19 is rare but fatal and is characterized by an aggressive clinical course and delayed diagnosis.Our report documents a case of disseminated mucormycosis after COVID-19 infection.This is a rare pathological autopsy report on COVID-19-associated mucormycosis.CASE SUMMARY A 58-year-old man was transferred to our hospital with severe COVID-19 pneumonia.During treatment for acute respiratory distress syndrome,he developed intra-abdominal bleeding that required a right hemicolectomy and ileostomy for hemostasis.The ileostoma and surgical wound developed necrosis followed by sepsis and multi-organ failure,which led to death.An autopsy revealed multiple thrombi associated with Rhizopus oryzae infection,which led to the necrosis of multiple infected organs.CONCLUSION Early suspicion and diagnosis followed by treatment are keys to better outcomes of mucormycosis in patients with severe COVID-19.

关 键 词：COVID-19 MUCORMYCOSIS Mucorales infection Rhizopus oryzae SARS-Co V-2 Case report 

分 类 号：R519[医药卫生—内科学]