Utility of cardiac bioenzymes in predicting cardiovascular outcomes in SARS-CoV-2  

作　　者：Anjani Muthyala Sandeep Sasidharan Kevin John John Amos Lal Ajay K Mishra 

机构地区：[1]Department of Internal Medicine,Saint Vincent Hospital,Worcester,MA 01608,United States [2]Department of Critical Care,Belivers Church Medical College Hospital,Thiruvalla 689103,Kerela,India [3]Department of Medicine,Division of Pulmonary and Critical Care Medicine,Mayo Clinic,Rochester,MN 55905,United States [4]Department of Cardiology,Saint Vincent Hospital,Worcester,MA 01608,United States

出　　处：《World Journal of Virology》2022年第5期375-390,共16页世界病毒学杂志

摘　　要：BACKGROUND Cardiovascular complications have been increasingly recognized in the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)associated coronavirus disease 2019(COVID-19).Cardiac biomarkers are released because of this ongoing cardiovascular injury and can act as surrogate markers to assess the disease severity.AIM To review the variation and utility of these biomarkers in COVID-19 to ascertain their role in diagnosis,prognosis and clinical outcomes of the disease.METHODS We performed a literature search in PubMed,Medline and the Reference Citation Analysis(RCA),using the search terms“COVID-19”and“cardiac bioenzymes”or“cardiac biomarkers”.Additionally,we also used the latest reference citation analysis tool to identify more articles.RESULTS Cardiac troponin has been consistently elevated in patients with COVID-19 associated myocarditis,and strongly correlated with adverse prognosis.Natriuretic peptides including brain natriuretic peptide(BNP)and pro-BNP is elevated in patients with COVID-19 associated cardiac injury,irrespective of their prior heart failure status,and independently correlated with worst outcomes.Alongside these traditional biomarkers,novel cardiac bioenzymes including presepsin,soluble ST2 and copeptin,are also increasingly recognized as markers of cardiovascular injury in COVID-19 and can be associated with poor outcomes.CONCLUSION Assessment of cardiac bioenzymes at admission and their serial monitoring can help assess the severity of disease and predict mortality in patients with SARS-CoV-2 infection.Future studies are needed to elude the critical importance of novel biomarkers.

关 键 词：SARS-CoV-2 TROPONIN Brain natriuretic peptide Prognosis OUTCOMES Heart failure 

分 类 号：R54[医药卫生—心血管疾病]