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作 者:Qiang Fu Yonghui Wang Fajun Nan
机构地区:[1]Department of Medicinal Chemistry,School of Pharmacy,Fudan University,826 Zhangheng Road,Shanghai 201203,China [2]State Key Laboratory of Drug Research,National Center for Drug Screening,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,555 Zuchongzhi Road,Shanghai 201203,China [3]Drug Discovery Shandong Laboratory,Bohai Rim Advanced Research Institute for Drug Discovery,Yantai,Shandong 264117,China
出 处:《Chinese Journal of Chemistry》2022年第13期1566-1570,共5页中国化学(英文版)
摘 要:The natural products of dispirocochlearoids are complex Ganoderma meroterpenoids featuring a 6/6/5/6/6/6 ring system and are selective cox-2 inhibitors.Herein,we describe our progress regarding the total synthesis of dispirocochlearoids A-C,in which a hexacyclic skeleton was constructed firstly.The key steps of this work involve an intermolecular[4+2]cycloaddition reaction,a ring cleavage approach via Ticla,and the installation of a profoundly sterically hindering lactone.
关 键 词:Natural products Dispirocochlearoids Hexacyclic skeleton CYCLOADDITION Total synthesis
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