Construction of the Hexacyclic Core of Dispirocochlearoids A-C via a Diels-Alder Reaction  

作　　者：Qiang Fu Yonghui Wang Fajun Nan 

机构地区：[1]Department of Medicinal Chemistry,School of Pharmacy,Fudan University,826 Zhangheng Road,Shanghai 201203,China [2]State Key Laboratory of Drug Research,National Center for Drug Screening,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,555 Zuchongzhi Road,Shanghai 201203,China [3]Drug Discovery Shandong Laboratory,Bohai Rim Advanced Research Institute for Drug Discovery,Yantai,Shandong 264117,China

出　　处：《Chinese Journal of Chemistry》2022年第13期1566-1570,共5页中国化学（英文版）

摘　　要：The natural products of dispirocochlearoids are complex Ganoderma meroterpenoids featuring a 6/6/5/6/6/6 ring system and are selective cox-2 inhibitors.Herein,we describe our progress regarding the total synthesis of dispirocochlearoids A-C,in which a hexacyclic skeleton was constructed firstly.The key steps of this work involve an intermolecular[4+2]cycloaddition reaction,a ring cleavage approach via Ticla,and the installation of a profoundly sterically hindering lactone.

关 键 词：Natural products Dispirocochlearoids Hexacyclic skeleton CYCLOADDITION Total synthesis 

分 类 号：O62[理学—有机化学]