新鲜或冷冻周期胚胎移植对子宫内膜异位症患者妊娠结局的影响  

Effect of fresh or thawed cycle embryo transfer on pregnancy outcome in patients with endometriosis

作　　者：李淑欣 徐珉[2] 叶虹 LI Shu-xin;XU Min;YE Hong(Department of Gynecological Reproductive Center,the Second Clinical Medical College,Guangzhou University of Chinese Medicine,Guangzhou Guangdong 510405,China;Department of Gynecological Reproductive Center,Guangdong Hospital of Traditional Chinese Medicine,Guangzhou Guangdong 510120,China)

机构地区：[1]广州中医药大学第二临床医学院妇科生殖中心,广东广州510405 [2]广东省中医院妇科生殖中心,广东广州510120

出　　处：《临床和实验医学杂志》2022年第17期1848-1852,共5页Journal of Clinical and Experimental Medicine

基　　金：国家中医药管理局课题(编号:1199ws02);广东省中医院中医药科学技术研究专项项目(编号:NY2019ML02)。

摘　　要：目的研究新鲜周期和冷冻周期胚胎移植对子宫内膜异位症不孕患者妊娠结局的影响。方法回顾性分析2014年8月至2021年2月在广东省中医院妇科生殖中心接受辅助生殖技术助孕的子宫内膜异位症不孕患者401例临床资料,其中新鲜周期胚胎移植292例(新鲜周期组),冷冻周期胚胎移植109例(冷冻周期组)。比较新鲜周期组和冷冻周期组的一般临床资料、促排资料、临床配子及胚胎资料、妊娠及新生儿结局资料,并分析新鲜周期组中活产组和非活产组促排资料、临床配子及胚胎资料的差异。结果新鲜周期组的人绒毛膜促性腺激素(HCG)日雌二醇水平、获卵总数和可利用胚胎数目为(10383.07±4278.64)pmol/L、(9.84±4.49)个、(5.80±3.36)个,均显著低于冷冻周期组[(14371.08±6811.62)pmol/L、(12.52±4.89)个、(7.12±3.75)个],差异均有统计学意义(P<0.05)。新鲜周期组的临床妊娠率及活产率为64.4%、56.8%,均显著高于冷冻周期组(47.7%、41.3%),差异均有统计学意义(P<0.05)。新鲜周期中活产组的体重指数为(20.90±2.22)kg/m 2,显著低于非活产组[(21.87±3.26)kg/m 2],且获卵总数、优质胚胎数目及移植优胚数目为(10.31±4.71)、(2.63±2.08)、(1.25±0.71)个,均显著高于非活产组[(9.24±4.12)、(2.25±2.36)、(1.02±0.77)个],差异均有统计学意义(P<0.05)。结论采用新鲜胚胎移植可以有效改善子宫内膜异位症不孕患者的妊娠结局。Objective To analysis the effect of fresh or thawed cycle embryo transfer on pregnancy outcome in patients with endometriosis.Methods The clinical data of 401 infertile patients with endometriosis who received assisted reproductive technology in the Gynecological Reproductive Center of Guangdong Hospital of Traditional Chinese Medicine from August 2014 to February 2021 were retrospectively analyzed,including 292 cases of fresh cycle embryo transfer(fresh cycle group)and 109 cases of frozen cycle embryo transfer(frozen cycle group).The general clinical data,ovulation promotion data,clinical gamete and embryo data,pregnancy and neonatal outcome data of fresh cycle group and frozen cycle group were compared,and the differences of ovulation promotion data,clinical gamete and embryo data between live birth group and non live birth group in fresh cycle group were analyzed.Results The level of human chorionic gonadotropin(HCG)daily estrogen,the total number of eggs retrieved and the number of available embryos in the fresh cycle group were(10383.07±4278.64)pmol/L,(9.84±4.49)pieces,(5.80±3.36)pieces,which were significantly lower than the freezing cycle group[(14371.08±6811.62)pmol/L,(12.52±4.89)pieces,(7.12±3.75)pieces],the differences were statistically significant(P<0.05).The clinical pregnancy rate and the live birth rate in the fresh cycle group were 64.4%,56.8%,which were significantly higher than those in the freezing cycle group(47.7%,41.3%,)the differences were statistically significant(P<0.05).The BMI in the fresh cycle group was(20.90±2.22)kg/m 2,which was significantly lower than that in the non-living cycle group[(21.87±3.26)kg/m 2],and the total number of eggs obtained,the number of high-quality embryos and the number of transplanted embryos were(10.31±4.71),(2.63±2.08),(1.25±0.71)pieces,which were significantly higher than those in the non-living cycle group[(9.24±4.12),(2.25±2.36),(1.02±0.77)pieces],the differences were statistically significant(P<0.05).Conclusion Fresh embryo transfer can e

关 键 词：子宫内膜异位症 新鲜胚胎移植 冷冻胚胎移植 获卵总数 妊娠结局 

分 类 号：R714.8[医药卫生—妇产科学]