椎间盘退变机制及修复生物工程支架研究进展  

Advances in research of the mechanisms and bioengineered scaffolds for disc degeneration repairing

作　　者：宋婵婵 冉兵[2,3,4] 宗毅 陈榕 林志坚 钟瑞丹 魏俊 SONG Chanchan;RAN Bing;ZONG Yi;CHEN Rong;LIN Zhijian;ZHONG Ruidan;WEI Jun(Gannan Medical University;Department of Pain,The First Affiliated Hospital of Gannan Medical University;The institute of Pain,Gannan Medical University;Engineering and Technology Research Center of Pain Medical of Gazhou,Ganzhou 341000,China)

机构地区：[1]赣南医学院 [2]赣南医学院第一附属医院疼痛科 [3]赣南医学院疼痛医学研究所 [4]赣州市疼痛医学工程技术研究中心,赣州341000

出　　处：《中国疼痛医学杂志》2022年第9期657-663,共7页Chinese Journal of Pain Medicine

基　　金：2021年度省卫生健康委科技计划项目(202130632);赣南医学院第一附属医院博士启动基金项目(QD071);赣南医学院科技创新特色建设团队课题(TS202004)。

摘　　要：腰椎间盘突出是腰痛的主要原因,临床发病率高。探索椎间盘突出的主要机制和根治方法具有较大的临床意义。近年来,生物工程支架用于修复各类疾病的研究层出不穷,并在椎间盘退变修复方面展现出较大潜力。本文拟对腰椎间盘退变的主要机制进行总结以及对腰椎间盘退变修复相关生物工程支架进行综述,以为后续椎间盘退变研究提供参考。Lumbar intervertebral disc herniation,which is a major cause of lower back pain,has a high clinical morbidity.Given the prevalence of this disease,exploring the main mechanisms to develop the essential treatments of disc degeneration is imperative.In recent years,many reserachers have focused on using bioengineered scaffolds in treating different diseases,and this therapy shown huge potential in disc degeneration repairing.This review will summarize both the main mechanisms and bioengineered scaffolds of lumbar disc degeneration and conclude the characteristics of various scaffolds.

关 键 词：腰椎间盘 退变机制 修复 生物支架 

分 类 号：R681.53[医药卫生—骨科学]