Electrochemical Synthesis of Sulfonyl Fluorides with Triethylamine Hydrofluoride  

作　　者：Lei Zhang Xu Cheng Qi-Lin Zhou 

机构地区：[1]State Key Laboratory and Institute of Elemento-Organic Chemistry,College of Chemistry,Nankai University,Tianjin 300071,China [2]Institute of Chemistry and Biomedical Sciences,Jjiangsu Key Laboratory of Advanced Organic Materials,National Demon-stration Center for Experimental Chemistry Education,School of Chemistry and Chemical Engineering,Nanjing University,Nanjing,Jjiangsu 210023,China

出　　处：《Chinese Journal of Chemistry》2022年第14期1687-1692,共6页中国化学（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.21790332,22071105,and 22031008);by the QingLan Project of Jiangsu Education Department.

摘　　要：Hydrofluoride is an industry-preferred fluoride source,and finds extensively application to manufacture diverse fluoro chemicals.The Et3N-3HF complex is a liquid HF with improve safety.In this work,we report electrochemical synthesis of a series of sulfonyl fluoride with Et3N-3HF as fluoride source.The sulfinic salt is a smell-less,non-volatile,and air-stable sulfur source in this reaction.With the combination of Et3N-3HF and aryl/alkyl sulfinic salt,the sulfonyl fluorides are achieved without the use of external oxidant.In addition,we demonstrate further advantage in a tandem reaction involving Pd-catalyzed C—S cross-coupling and formation of S—F bond.A variety of functional groups including amino acids,heterocycles,halides are well tolerated.

关 键 词：Electrochemicstry Fluorides Click chemistry Sulfinic salt DEHYDROGENATION 

分 类 号：O62[理学—有机化学]