痛风CT影像学特征与临床相关危险因素分析  

CT imaging features and clinical risk factors of gout

作　　者：乐剑平 胡军平 匡海山 LE Jian-ping;HU Jun-ping;KUANG Hai-shan(Department of Medical Imaging,Wuhu Traditional Chinese Medicine Hospital,Wuhu Anhui 241000,China;Department of Endocrinology,Wuhu Traditional Chinese Medicine Hospital,Wuhu Anhui 241000,China)

机构地区：[1]芜湖市中医医院医学影像科,安徽芜湖241000 [2]芜湖市中医医院内分泌科,安徽芜湖241000

出　　处：《临床和实验医学杂志》2022年第18期2000-2003,共4页Journal of Clinical and Experimental Medicine

基　　金：安徽省科技攻关计划资助项目(编号:1905a0802091)。

摘　　要：目的探讨痛风患者的CT影像学特征与临床相关危险因素之间的关系。方法回顾性分析2018年10月至2022年1月在芜湖市中医医院住院的痛风患者104例,分析其CT影像学特征:尿酸结晶沉积的有无、数量、形态及有无骨质侵蚀,并收集相关临床资料,采用Logistic回归和Poisson回归分析与影像学特征相关的危险因素。结果104例患者中75例有尿酸盐结晶沉积,其中尿酸盐结晶数量最少1处,最多15处,中位数为3(2,7);所有患者中有骨质侵蚀者16例。尿酸盐结晶形态为小结节者77例;为条片状者27例。应用Logistic及Poisson回归显示女性是尿酸盐结晶沉积、数量的保护因素(P<0.05);病程是痛风患者发生尿酸盐结晶沉积、数量、骨质侵蚀、条片状形态的危险因素(P<0.05);血尿酸、甘油三酯水平是尿酸盐结晶发生骨质侵蚀危险因素(P<0.05)。血尿酸、血肌酐是尿酸盐结晶数量增多的危险因素(P<0.05)。同时骨质侵蚀患者的年龄、肌酐、总胆固醇、血糖均高于无骨质侵蚀者,但差异无统计学意义(P>0.05)。结论痛风CT影像学特征与临床相关危险因素关系密切。相比尿酸盐结晶沉积有无及形态特征,尿酸盐结晶数量及骨质侵蚀情况是评价痛风的重要指标,能有效反映患者的病情。掌握影像学特征与危险因素的关系有助于对痛风患者病情进展的掌握和干预。Objective To investigate the relationship between CT imaging features and clinical risk factors in patients with gout.Methods A total of 116 patients with gout hospitalized in Wuhu Traditional Chinese Medicine Hospital from October 2018 to January 2022 were retrospectively analyzed.According to the imaging features on CT:the presence,quantity,morphology and bone erosion of uric acid crystal deposition,the relevant clinical data were collected.Logistic regression and Poisson regression were used to analyze the risk factors associated with their imaging characteristics.Results Urate crystals were found in 75 of 104 patients,and the number of urate crystals ranged from 1 to 15,with a median of 3(2,7).There were 16 cases of bone erosion in all patients.The crystal form of urate was small nodules in 77 cases and strip-like in 27 cases.Logistic and Poisson regression showed that female was a protective factor for urate deposition and quantity(P<0.05);disease duration was an independent risk factor for urate deposition,quantity,bone erosion,and strip-like morphology in gout patients(P<0.05);serum uric acid and triglyceride levels were risk factors for bone erosion of urate crystals(P<0.05).Serum uric acid and serum creatinine were risk factors for increased gout(P<0.05).Meanwhile,the age,creatinine,total cholesterol and blood glucose of patients with bone erosion were higher than those without bone erosion,but the differences were not statistically significant(P>0.05).Conclusion CT imaging features of gout are closely related to clinical risk factors.Compared with urate crystal deposition and morphology,the number of urate crystals and bone erosion are important indicators for evaluating gout,which can effectively reflect the patient’s condition.Understanding the relationship between imaging features and risk factors is helpful to grasp and intervene the disease progression of gout patients.

关 键 词：痛风 CT 影像学特征 尿酸盐沉积 危险因素 

分 类 号：R589.7[医药卫生—内分泌]