去除白细胞输血对预防非溶血性输血后发热反应的效果探讨  

The effect of leukocyte-depleted transfusion on the prevention of febrile non-hemolytic transfusion reaction

作　　者：景秀芹 JING Xiu-qin(Central Blood Storage Station,Fengcheng Health Service Center,Fengcheng 118100,China)

机构地区：[1]辽宁省凤城市卫生健康服务中心中心储血站,118100

出　　处：《中国现代药物应用》2022年第18期170-172,共3页Chinese Journal of Modern Drug Application

摘　　要：目的 探讨去除白细胞输血对预防非溶血性输血后发热反应的效果。方法 600例接受输血治疗的患者,通过随机数字表法分为对照组与观察组,各300例。对照组采取未去除白细胞的红细胞悬液进行输血,观察组采取去除白细胞的少白细胞红细胞悬液进行输血。比较两组的血常规指标[白细胞计数(WBC)、红细胞计数(RBC)与血小板计数(PLT)及血红蛋白]、非溶血性输血后发热反应发生情况及不同输血次数的非溶血性输血后发热反应发生情况。结果 观察组白细胞计数(0.003±0.001)×10^(9)/L、血小板计数(15.42±4.31)×10^(9)/L明显低于对照组的(6.450±1.720)×10^(9)/L、(161.73±55.34)×10^(9)/L,差异具有统计学意义(P<0.05);两组红细胞计数、血红蛋白水平比较,差异无统计学意义(P>0.05)。观察组1次输血患者的非溶血性输血后发热反应发生率为0.81%(2/247), 2次输血患者的发生率为3.03%(1/33),3次输血患者的发生率为5.00%(1/20);观察组1、2、3次输血患者的非溶血性输血后发热反应发生率比较,差异无统计学意义(P>0.05)。对照组1次输血患者的非溶血性输血后发热反应发生率为3.66%(9/246),2次输血患者的发生率为26.47%(9/34), 3次输血患者的发生率为30.00%(6/20);对照组2次输血及3次输血患者非溶血性输血后发热反应发生率明显高于1次输血患者,差异具有统计学意义(P<0.05)。观察组非溶血性输血后发热反应发生率为1.33%(4/300),低于对照组的8.00%(24/300),差异具有统计学意义(P<0.05)。结论 对患者采取去除白细胞输血能够有效预防非溶血性输血后发热反应,对于预防多次输血导致的非溶血性输血后发热反应发生效果明显,值得临床应用。Objective To discuss the effect of leukocyte-depleted transfusion on the prevention of febrile non-hemolytic transfusion reaction.Methods A total of 600 patients who received blood transfusion treatment were divided into control group and observation group by random numerical table,with 300 cases in each group.The control group received red blood cell suspension without leukocyte depletion for blood transfusion,and the observation group received leukocyte-depleted red blood cell suspension for blood transfusion.Both groups were compared in terms of blood routine indexes[white blood cell count(WBC),red blood cell count(RBC)and platelet count(PLT)and hemoglobin],occurrence of febrile non-hemolytic transfusion reaction and occurrence of febrile non-hemolytic transfusion reaction with different number of transfusions.Results The white blood cell count(0.003±0.001)×10^(9)/L and platelet count(15.42±4.31)×10^(9)/L in the observation group were significantly lower than(6.450±1.720)×10^(9)/L and(161.73±55.34)×10^(9)/L in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in red blood cell count and hemoglobin level between the two groups(P>0.05).The incidence of febrile non-hemolytic transfusion reaction in the observation group was 0.81%(2/247)in patients with 1 transfusion,3.03%(1/33)in patients with 2 transfusions,and 5.00%(1/20)in patients with 3 transfusions.In the observation group,there was no statistically significant difference in the incidence of febrile non-hemolytic transfusion reaction when comparing patients with 1,2 and 3 transfusions(P>0.05).The incidence of febrile non-hemolytic transfusion reaction in the control group was 3.66%(9/246)in patients with 1 transfusion,26.47%(9/34)in patients with 2 transfusions,and 30.00%(6/20)in patients with 3 transfusions.In the control group,the incidence of febrile non-hemolytic transfusion reaction of patients with 2 transfusions and 3 transfusions was significantly higher than that o

关 键 词：去除白细胞 非溶血性输血 发热反应 

分 类 号：R457.1[医药卫生—治疗学]