高速卡口货运司乘人员新型冠状病毒抗原与核酸双检测措施效果评估  

Efficiency of dual test of SARS-CoV-2 antigen and nucleic acid among freight truck drivers and workers passing through expressway toll gates

作　　者：洪航[1] 方挺[1] 丁克琴[1] 易波[1] 许国章[1] HONG Hang;FANG Ting;DING Ke-qin(Ningbo Municipal Center for Disease Control and Prevention,Ningbo,Zhejiang Province 315010,China)

机构地区：[1]宁波市疾病预防控制中心,宁波315010

出　　处：《中国公共卫生》2022年第8期965-967,共3页Chinese Journal of Public Health

基　　金：宁波市应急科技攻关重大专项(2022Z034);宁波市“科技创新2025”重大专项(2021Z021);宁波市医疗卫生品牌学科(PPXK2018-10);浙江省医学重点学科(07-013)。

摘　　要：目的对高速卡口货运司乘人员新型冠状病毒抗原与核酸双检测措施效果评估。方法对2022年3月20日—4月17日在宁波市北仑区8个高速卡口48734名有浙江省外旅居史货运的司乘人员进行新型冠状病毒抗原与核酸双检测,并对检测结果进行描述性统计分析。结果共检出9例Omicron变异株感染者,其中确诊病例6例(均为轻型),无症状感染者3例,未发现阳性感染者续发病例;抗原检测试剂的灵敏度和特异度分别为55.5%(5/9)和99.9%(48717/48725),阳性预测值和阴性预测值分别为38.5%(5/13)和99.9%(48717/48721);阳性感染者中抗原阳性组ORF1ab和N基因Ct值M(P_(25),P_(75))分别为19.0(17.1,21.5)、19.0(16.6,22.5),抗原阴性组Ct值均显著高于抗原阳性组(P<0.05)。结论抗原检测试剂灵敏度较低但特异度高。建议在高速卡口对货运司乘人员实施抗原与核酸双检测策略,既保障物流畅通,又有效降低输入性病例引起本土疫情风险。Objective To evaluate the efficiency of dual test of severe acute respiratory disease coronavirus 2(SARS-CoV-2)antigen and nucleic acid among freight truck drivers and workers passing through expressway toll gates.Methods Dual tests of SARS-CoV-2 antigen and nucleic acid were conducted among 48734 freight truck drivers and workers passing through 8 expressway toll gates in Ningbo city from provinces other than Zhejiang province during the period of March 20–April 17,2022.The test results were statistically analyzed.Results Totally 9 infections of SARS-CoV-2 Omicron variant were detected;of which,6 were diagnosed clinically as mild coronavirus disease 2019(COVID-19)case and 3 as asymptomatic infection.No subsequent COVID-19 case was confirmed.For the SARS-CoV-2 antigen test,the sensitivity and specificity were 55.5%(5/9)and 99.9%(48717/48725);the positive and negative predictive value were 38.5%(5/13)and 99.9%(48717/48721),respectively.For multiplex fluorescence PCR test of SARS-CoV-2 nucleic acid among the participants with positive SARS-CoV-2 antigen result,the Ct values of ORF1ab and N gene M(25th percentile,75th percentile)were 19.0(17.1,21.5)and 19.0(16.6,22.5);while,the Ct values of the participants with negative result was significantly higher than those of the participants with positive SARS-CoV-2 antigen result(P<0.05).Conclusion In this study,the sensitivity of SARS-CoV-2 antigen test is low but the specificity of the test is high for the detection of SARS-CoV-2 infection.The results suggest that dual test of SARS-CoV-2 antigen and nucleic acid should be implemented to reduce the risk of imported case-induced local COVID-19 epidemic.

关 键 词：新型冠状病毒 Omicron变异株 抗原检测 核酸检测 

分 类 号：R183[医药卫生—流行病学]