醒脑开窍针刺法联合药物对大脑中动脉狭窄患者脑灌注和微栓子信号的影响  

Effect of Xing Nao Kai Qiao Acupuncture Combined with Medicine Treatment on Cerebral Perfusion and Microembolic Signal in Patients with Middle Cerebral Artery Stenosis

作　　者：马龙 路凯[1] 马宇[1] 崔友祥[1] 孙云川[1] MA Long;LU Kai;MA Yu;CUI Youxiang;SUN Yunchuan(Cangzhou Hospital of Integrated TCM-WM,Hebei,Cangzhou 061001,China)

机构地区：[1]河北省沧州中西医结合医院,沧州061001

出　　处：《上海针灸杂志》2022年第10期959-963,共5页Shanghai Journal of Acupuncture and Moxibustion

基　　金：河北省中医药管理局科研计划项目(2022227)。

摘　　要：目的 观察醒脑开窍针刺法联合药物对大脑中动脉(MCA)狭窄患者脑灌注和微栓子信号(MES)的影响。方法 将104例MCA患者采用随机数字表法分为对照组和研究组,每组52例。对照组予常规西药治疗,研究组予醒脑开窍针刺法联合常规西药治疗。比较两组治疗前后脑灌注参数[相对脑血容量(rCBV)、相对脑血流量(rCBF)、相对平均通过时间(rMTT)和相对平均达峰时间(rTTP)]、MES阳性率和血管狭窄严重程度的变化,比较两组治疗期间的不良反应发生情况。结果 治疗后,两组r CBV和r CBF水平均升高(P<0.05),且研究组的水平均高于对照组(P<0.05);两组r MTT和rTTP水平均下降(P<0.05),且研究组的水平均低于对照组(P<0.05);两组MES阳性率和血管狭窄严重程度均较同组治疗前降低(P<0.05),且研究组低于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 醒脑开窍针刺法联合西药治疗可改善MCA狭窄患者的脑灌注水平,降低MES阳性率,并减轻血管狭窄严重程度。Objective To observe the effect of Xing Nao Kai Qiao acupuncture combined with Western medicine treatment with on cerebral perfusion and microembolic signal(MES) in patients with middle cerebral artery(MCA)stenosis. Method All of 104 patients with MCA were divided into a control group and a study group by random number table method, with 52 cases in each group. The control group was treated with conventional Western medicine,and the study group was treated with Xing Nao Kai Qiao acupuncture combined with conventional Western medicine.The changes of cerebral perfusion parameters [relative cerebral blood volume(rCBV), relative cerebral blood flow(r CBF), relative mean time to passage(rMTT) and relative mean time to peak(rTTP)], MES positive rate and severity of vascular stenosis were compared between the two groups before and after treatment, and the occurrence of adverse effects during the treatment period was compared between the two groups. Result After treatment, the levels of rCBV and rCBF increased in both groups(P<0.05), and they were higher in the study group than in the control group(P<0.05). The levels of rMTT and rTTP decreased in both groups(P<0.05), and they were lower in the study group than in the control group(P<0.05). The MES positive rate and the severity of stenosis in both groups were lower than those before treatment in the same group(P<0.05), and they were lower in the study group than in the control group(P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion Xing Nao Kai Qiao acupuncture plus Western medicine can improve the cerebral perfusion level, reduce the positive rate of MES, and reduce the severity of stenosis in patients with MCA stenosis.

关 键 词：针刺疗法 针药并用 梗死 大脑中动脉 脑灌注 脑血容量 微栓子信号 

分 类 号：R246.1[医药卫生—针灸推拿学]